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Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.
Ertekin-Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, Hella M, Jain S, Hackett A, Scanlin L, Kelly J, Kihiko-Ehman M, Neltner M, Hersh L, Kindy M, Markesbery W, Hutton M, de Andrade M, Petersen RC, Graff-Radford N, Estus S, Brookes AJ, Younkin SG. Ertekin-Taner N, et al. Among authors: younkin l, younkin sg. Hum Mol Genet. 2005 Feb 1;14(3):447-60. doi: 10.1093/hmg/ddi041. Epub 2004 Dec 22. Hum Mol Genet. 2005. PMID: 15615772
Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members.
Finch N, Baker M, Crook R, Swanson K, Kuntz K, Surtees R, Bisceglio G, Rovelet-Lecrux A, Boeve B, Petersen RC, Dickson DW, Younkin SG, Deramecourt V, Crook J, Graff-Radford NR, Rademakers R. Finch N, et al. Among authors: younkin sg. Brain. 2009 Mar;132(Pt 3):583-91. doi: 10.1093/brain/awn352. Epub 2009 Jan 21. Brain. 2009. PMID: 19158106 Free PMC article.
Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease.
Zou F, Carrasquillo MM, Pankratz VS, Belbin O, Morgan K, Allen M, Wilcox SL, Ma L, Walker LP, Kouri N, Burgess JD, Younkin LH, Younkin SG, Younkin CS, Bisceglio GD, Crook JE, Dickson DW, Petersen RC, Graff-Radford N, Younkin SG, Ertekin-Taner N. Zou F, et al. Among authors: younkin lh, younkin cs, younkin sg. Neurology. 2010 Feb 9;74(6):480-6. doi: 10.1212/WNL.0b013e3181d07654. Neurology. 2010. PMID: 20142614 Free PMC article.
Replication of CLU, CR1, and PICALM associations with alzheimer disease.
Carrasquillo MM, Belbin O, Hunter TA, Ma L, Bisceglio GD, Zou F, Crook JE, Pankratz VS, Dickson DW, Graff-Radford NR, Petersen RC, Morgan K, Younkin SG. Carrasquillo MM, et al. Among authors: younkin sg. Arch Neurol. 2010 Aug;67(8):961-4. doi: 10.1001/archneurol.2010.147. Epub 2010 Jun 14. Arch Neurol. 2010. PMID: 20554627 Free PMC article. Clinical Trial.
Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD.
Carrasquillo MM, Khan Qu, Murray ME, Krishnan S, Aakre J, Pankratz VS, Nguyen T, Ma L, Bisceglio G, Petersen RC, Younkin SG, Dickson DW, Boeve BF, Graff-Radford NR, Ertekin-Taner N. Carrasquillo MM, et al. Among authors: younkin sg. Neurology. 2014 Apr 22;82(16):1455-62. doi: 10.1212/WNL.0000000000000335. Epub 2014 Mar 26. Neurology. 2014. PMID: 24670887 Free PMC article.
Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease.
Carrasquillo MM, Crook JE, Pedraza O, Thomas CS, Pankratz VS, Allen M, Nguyen T, Malphrus KG, Ma L, Bisceglio GD, Roberts RO, Lucas JA, Smith GE, Ivnik RJ, Machulda MM, Graff-Radford NR, Petersen RC, Younkin SG, Ertekin-Taner N. Carrasquillo MM, et al. Among authors: younkin sg. Neurobiol Aging. 2015 Jan;36(1):60-7. doi: 10.1016/j.neurobiolaging.2014.07.042. Epub 2014 Aug 4. Neurobiol Aging. 2015. PMID: 25189118 Free PMC article.
Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families.
Ertekin-Taner N, Younkin LH, Yager DM, Parfitt F, Baker MC, Asthana S, Hutton ML, Younkin SG, Graff-Radford NR. Ertekin-Taner N, et al. Among authors: younkin lh, younkin sg. Neurology. 2008 Feb 19;70(8):596-606. doi: 10.1212/01.WNL.0000278386.00035.21. Epub 2007 Oct 3. Neurology. 2008. PMID: 17914065
273 results