Al-Fayoumi S - Search Results

1

AI & experimental-based discovery and preclinical IND-enabling studies of selective BMX inhibitors for development of cancer therapeutics.

Elsanhoury R, Alasmari A, Parupathi P, Jumaa M, Al-Fayoumi S, Kumar A, Khashan R, Nazzal S, Fayyad AA. Elsanhoury R, et al. Among authors: al fayoumi s. Int J Pharm. 2023 Oct 15;645:123384. doi: 10.1016/j.ijpharm.2023.123384. Epub 2023 Sep 8. Int J Pharm. 2023. PMID: 37678472

2

Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures.

Singer JW, Al-Fayoumi S, Taylor J, Velichko S, O'Mahony A. Singer JW, et al. Among authors: al fayoumi s. PLoS One. 2019 Sep 27;14(9):e0222944. doi: 10.1371/journal.pone.0222944. eCollection 2019. PLoS One. 2019. PMID: 31560729 Free PMC article.

3

Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy.

Singer JW, Fleischman A, Al-Fayoumi S, Mascarenhas JO, Yu Q, Agarwal A. Singer JW, et al. Among authors: al fayoumi s. Oncotarget. 2018 Sep 7;9(70):33416-33439. doi: 10.18632/oncotarget.26058. eCollection 2018 Sep 7. Oncotarget. 2018. PMID: 30279971 Free PMC article. Review.

4

Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis.

Al-Fayoumi S, Hashiguchi T, Shirakata Y, Mascarenhas J, Singer JW. Al-Fayoumi S, et al. J Exp Pharmacol. 2018 May 9;10:9-17. doi: 10.2147/JEP.S150729. eCollection 2018. J Exp Pharmacol. 2018. PMID: 29785143 Free PMC article.

5

Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis: A Randomized Clinical Trial.

Mascarenhas J, Hoffman R, Talpaz M, Gerds AT, Stein B, Gupta V, Szoke A, Drummond M, Pristupa A, Granston T, Daly R, Al-Fayoumi S, Callahan JA, Singer JW, Gotlib J, Jamieson C, Harrison C, Mesa R, Verstovsek S. Mascarenhas J, et al. Among authors: al fayoumi s. JAMA Oncol. 2018 May 1;4(5):652-659. doi: 10.1001/jamaoncol.2017.5818. JAMA Oncol. 2018. PMID: 29522138 Free PMC article. Clinical Trial.

6

Phase 1/2 study of pacritinib, a next generation JAK2/FLT3 inhibitor, in myelofibrosis or other myeloid malignancies.

Verstovsek S, Odenike O, Singer JW, Granston T, Al-Fayoumi S, Deeg HJ. Verstovsek S, et al. Among authors: al fayoumi s. J Hematol Oncol. 2016 Dec 8;9(1):137. doi: 10.1186/s13045-016-0367-x. J Hematol Oncol. 2016. PMID: 27931243 Free PMC article. Clinical Trial.

7

Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor.

Singer JW, Al-Fayoumi S, Ma H, Komrokji RS, Mesa R, Verstovsek S. Singer JW, et al. Among authors: al fayoumi s. J Exp Pharmacol. 2016 Aug 16;8:11-9. doi: 10.2147/JEP.S110702. eCollection 2016. J Exp Pharmacol. 2016. PMID: 27574472 Free PMC article.

8

Tolerability and toxicological profile of pixantrone (Pixuvri®) in juvenile mice. Comparative study with doxorubicin.

Longo M, Della Torre P, Allievi C, Morisetti A, Al-Fayoumi S, Singer JW. Longo M, et al. Among authors: al fayoumi s. Reprod Toxicol. 2014 Jul;46:20-30. doi: 10.1016/j.reprotox.2014.02.006. Epub 2014 Mar 3. Reprod Toxicol. 2014. PMID: 24602559

9

Phase 1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle modulator, in healthy volunteers.

Kubota R, Al-Fayoumi S, Mallikaarjun S, Patil S, Bavik C, Chandler JW. Kubota R, et al. Among authors: al fayoumi s. Retina. 2014 Mar;34(3):603-9. doi: 10.1097/01.iae.0000434565.80060.f8. Retina. 2014. PMID: 24056528 Clinical Trial.

10

Pharmacokinetics, safety and tolerability of single and multiple oral doses of aliskiren in healthy Chinese subjects: a randomized, single-blind, parallel-group, placebo-controlled study.

Hu P, Bartlett M, Karan RS, Jiang J, Zhang S, Zhang J, Howard D, Yeh CM, Al-Fayoumi S, Jarugula V, Dole WP. Hu P, et al. Among authors: al fayoumi s. Clin Drug Investig. 2010;30(4):221-8. doi: 10.2165/11533050-000000000-00000. Clin Drug Investig. 2010. PMID: 20192280 Clinical Trial.

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