Middleton RJ - Search Results

1

New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.

Middleton RJ, Briddon SJ, Cordeaux Y, Yates AS, Dale CL, George MW, Baker JG, Hill SJ, Kellam B. Middleton RJ, et al. J Med Chem. 2007 Feb 22;50(4):782-93. doi: 10.1021/jm061279i. Epub 2007 Jan 24. J Med Chem. 2007. PMID: 17249651

2

Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.

Baker JG, Middleton R, Adams L, May LT, Briddon SJ, Kellam B, Hill SJ. Baker JG, et al. Br J Pharmacol. 2010 Feb;159(4):772-86. doi: 10.1111/j.1476-5381.2009.00488.x. Epub 2010 Jan 26. Br J Pharmacol. 2010. PMID: 20105183 Free PMC article.

3

Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells.

Briddon SJ, Middleton RJ, Cordeaux Y, Flavin FM, Weinstein JA, George MW, Kellam B, Hill SJ. Briddon SJ, et al. Among authors: middleton rj. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4673-8. doi: 10.1073/pnas.0400420101. Epub 2004 Mar 16. Proc Natl Acad Sci U S A. 2004. PMID: 15070776 Free PMC article.

4

Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level.

Briddon SJ, Middleton RJ, Yates AS, George MW, Kellam B, Hill SJ. Briddon SJ, et al. Among authors: middleton rj. Faraday Discuss. 2004;126:197-207; discussion 245-54. doi: 10.1039/b307407b. Faraday Discuss. 2004. PMID: 14992407

5

Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.

Baker JG, Adams LA, Salchow K, Mistry SN, Middleton RJ, Hill SJ, Kellam B. Baker JG, et al. Among authors: middleton rj. J Med Chem. 2011 Oct 13;54(19):6874-87. doi: 10.1021/jm2008562. Epub 2011 Sep 16. J Med Chem. 2011. PMID: 21870877 Free PMC article.

6

Fluorophore-tagged GPCR ligands.

Middleton RJ, Kellam B. Middleton RJ, et al. Curr Opin Chem Biol. 2005 Oct;9(5):517-25. doi: 10.1016/j.cbpa.2005.08.016. Curr Opin Chem Biol. 2005. PMID: 16125436 Review.

7

Quantitative measurement of sulforaphane, iberin and their mercapturic acid pathway metabolites in human plasma and urine using liquid chromatography-tandem electrospray ionisation mass spectrometry.

Al Janobi AA, Mithen RF, Gasper AV, Shaw PN, Middleton RJ, Ortori CA, Barrett DA. Al Janobi AA, et al. Among authors: middleton rj. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Dec 5;844(2):223-34. doi: 10.1016/j.jchromb.2006.07.007. Epub 2006 Aug 23. J Chromatogr B Analyt Technol Biomed Life Sci. 2006. PMID: 16931178

8

Quantitative analysis of the major constituents of St John's wort with HPLC-ESI-MS.

Chandrasekera DH, Welham KJ, Ashton D, Middleton R, Heinrich M. Chandrasekera DH, et al. J Pharm Pharmacol. 2005 Dec;57(12):1645-52. doi: 10.1211/jpp.57.12.0015. J Pharm Pharmacol. 2005. PMID: 16354409

9

GC-MS identification of sympathomimetic amine drugs in urine: rapid methodology applicable for emergency clinical toxicology.

Valentine JL, Middleton R. Valentine JL, et al. J Anal Toxicol. 2000 Apr;24(3):211-22. doi: 10.1093/jat/24.3.211. J Anal Toxicol. 2000. PMID: 10774541

10

Identification of urinary benzodiazepines and their metabolites: comparison of automated HPLC and GC-MS after immunoassay screening of clinical specimens.

Valentine JL, Middleton R, Sparks C. Valentine JL, et al. J Anal Toxicol. 1996 Oct;20(6):416-24. doi: 10.1093/jat/20.6.416. J Anal Toxicol. 1996. PMID: 8889678

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