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Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats.
Shichijo M, Sugimoto H, Nagao K, Inbe H, Encinas JA, Takeshita K, Bacon KB, Gantner F. Shichijo M, et al. Among authors: takeshita k. J Pharmacol Exp Ther. 2003 Nov;307(2):518-25. doi: 10.1124/jpet.103.055442. Epub 2003 Sep 15. J Pharmacol Exp Ther. 2003. PMID: 12975488
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents.
Yamamoto N, Takeshita K, Shichijo M, Kokubo T, Sato M, Nakashima K, Ishimori M, Nagai H, Li YF, Yura T, Bacon KB. Yamamoto N, et al. Among authors: takeshita k. J Pharmacol Exp Ther. 2003 Sep;306(3):1174-81. doi: 10.1124/jpet.103.052316. Epub 2003 May 23. J Pharmacol Exp Ther. 2003. PMID: 12766258
A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.
Ziegelbauer K, Gantner F, Lukacs NW, Berlin A, Fuchikami K, Niki T, Sakai K, Inbe H, Takeshita K, Ishimori M, Komura H, Murata T, Lowinger T, Bacon KB. Ziegelbauer K, et al. Among authors: takeshita k. Br J Pharmacol. 2005 May;145(2):178-92. doi: 10.1038/sj.bjp.0706176. Br J Pharmacol. 2005. PMID: 15753951 Free PMC article.
Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.
Murata T, Shimada M, Sakakibara S, Yoshino T, Kadono H, Masuda T, Shimazaki M, Shintani T, Fuchikami K, Sakai K, Inbe H, Takeshita K, Niki T, Umeda M, Bacon KB, Ziegelbauer KB, Lowinger TB. Murata T, et al. Among authors: takeshita k. Bioorg Med Chem Lett. 2003 Mar 10;13(5):913-8. doi: 10.1016/s0960-894x(02)01046-6. Bioorg Med Chem Lett. 2003. PMID: 12617920
1,324 results