Komura H - Search Results

1

Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4.

Okigami H, Takeshita K, Tajimi M, Komura H, Albers M, Lehmann TE, Rölle T, Bacon KB. Okigami H, et al. Among authors: komura h. Eur J Pharmacol. 2007 Mar 22;559(2-3):202-9. doi: 10.1016/j.ejphar.2006.11.065. Epub 2006 Dec 12. Eur J Pharmacol. 2007. PMID: 17234179

2

A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.

Ziegelbauer K, Gantner F, Lukacs NW, Berlin A, Fuchikami K, Niki T, Sakai K, Inbe H, Takeshita K, Ishimori M, Komura H, Murata T, Lowinger T, Bacon KB. Ziegelbauer K, et al. Among authors: komura h. Br J Pharmacol. 2005 May;145(2):178-92. doi: 10.1038/sj.bjp.0706176. Br J Pharmacol. 2005. PMID: 15753951 Free PMC article.

3

Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents.

Murata T, Shimada M, Sakakibara S, Yoshino T, Masuda T, Shintani T, Sato H, Koriyama Y, Fukushima K, Nunami N, Yamauchi M, Fuchikami K, Komura H, Watanabe A, Ziegelbauer KB, Bacon KB, Lowinger TB. Murata T, et al. Among authors: komura h. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4019-22. doi: 10.1016/j.bmcl.2004.05.041. Bioorg Med Chem Lett. 2004. PMID: 15225718

4

[High throughput screening of pharmacokinetics and metabolism in drug discovery (III)--investigation on in- silico model for membrane permeability and CYP1A2 inhibition].

Komura H, Shigemoto Y, Kawahara I, Matsuda K, Ano R, Murayama Y, Moriwaki T, Yoshida NH. Komura H, et al. Yakugaku Zasshi. 2005 Jan;125(1):141-7. doi: 10.1248/yakushi.125.141. Yakugaku Zasshi. 2005. PMID: 15635285 Free article. Japanese.

5

[High throughput screening of pharmacokinetics and metabolism in drug discovery (II)--investigation on in vitro and in vivo correlation in drug metabolism screening].

Komura H, Matsuda K, Shigemoto Y, Kawahara I, Ano R, Murayama Y, Moriwaki T, Yoshida NH. Komura H, et al. Yakugaku Zasshi. 2005 Jan;125(1):131-9. doi: 10.1248/yakushi.125.131. Yakugaku Zasshi. 2005. PMID: 15635284 Free article. Japanese.

6

Species difference in nisoldipine oxidation activity in the small intestine.

Komura H, Yasuda M, Yoshida NH, Sugiyama Y. Komura H, et al. Drug Metab Pharmacokinet. 2002;17(5):427-36. doi: 10.2133/dmpk.17.427. Drug Metab Pharmacokinet. 2002. PMID: 15618694 Free article.

7

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.

Banasik M, Komura H, Shimoyama M, Ueda K. Banasik M, et al. Among authors: komura h. J Biol Chem. 1992 Jan 25;267(3):1569-75. J Biol Chem. 1992. PMID: 1530940 Free article.

8

[High throughput screening of pharmacokinetics and metabolism in drug discovery (I)--establishment of assessment system for absorption to compounds with a wide diversity of physical properties].

Komura H, Kawahara I, Shigemoto Y, Matsuda K, Ano R, Murayama Y, Moriwaki T, Yoshida NH. Komura H, et al. Yakugaku Zasshi. 2005 Jan;125(1):121-30. doi: 10.1248/yakushi.125.121. Yakugaku Zasshi. 2005. PMID: 15635283 Free article. Japanese.

9

Inhibition of poly(ADP-ribose) synthetase by unsaturated fatty acids, vitamins and vitamin-like substances.

Banasik M, Komura H, Ueda K. Banasik M, et al. Among authors: komura h. FEBS Lett. 1990 Apr 24;263(2):222-4. doi: 10.1016/0014-5793(90)81378-2. FEBS Lett. 1990. PMID: 2139856 Free article.

10

Constructing an In Silico Three-Class Predictor of Human Intestinal Absorption With Caco-2 Permeability and Dried-DMSO Solubility.

Esaki T, Ohashi R, Watanabe R, Natsume-Kitatani Y, Kawashima H, Nagao C, Komura H, Mizuguchi K. Esaki T, et al. Among authors: komura h. J Pharm Sci. 2019 Nov;108(11):3630-3639. doi: 10.1016/j.xphs.2019.07.014. Epub 2019 Jul 25. J Pharm Sci. 2019. PMID: 31351866

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