Sakagami K - Search Results

1

Scalable synthesis of (+)-2-amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid as a potent and selective group II metabotropic glutamate receptor agonist.

Sakagami K, Kumagai T, Taguchi T, Nakazato A. Sakagami K, et al. Chem Pharm Bull (Tokyo). 2007 Jan;55(1):37-43. doi: 10.1248/cpb.55.37. Chem Pharm Bull (Tokyo). 2007. PMID: 17202699 Free article.

2

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity.

Chaki S, Yoshikawa R, Hirota S, Shimazaki T, Maeda M, Kawashima N, Yoshimizu T, Yasuhara A, Sakagami K, Okuyama S, Nakanishi S, Nakazato A. Chaki S, et al. Among authors: sakagami k. Neuropharmacology. 2004 Mar;46(4):457-67. doi: 10.1016/j.neuropharm.2003.10.009. Neuropharmacology. 2004. PMID: 14975669

3

Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists.

Nakazato A, Sakagami K, Yasuhara A, Ohta H, Yoshikawa R, Itoh M, Nakamura M, Chaki S. Nakazato A, et al. Among authors: sakagami k. J Med Chem. 2004 Aug 26;47(18):4570-87. doi: 10.1021/jm0400294. J Med Chem. 2004. PMID: 15317467

4

In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of mgs0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid), a potent metabotropic glutamate receptor antagonist.

Nakamura M, Kawakita Y, Yasuhara A, Fukasawa Y, Yoshida K, Sakagami K, Nakazato A. Nakamura M, et al. Among authors: sakagami k. Drug Metab Dispos. 2006 Mar;34(3):369-74. doi: 10.1124/dmd.105.006213. Epub 2005 Dec 2. Drug Metab Dispos. 2006. PMID: 16326817

5

Synthesis, in vitro pharmacology, and structure-activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists.

Yasuhara A, Sakagami K, Yoshikawa R, Chaki S, Nakamura M, Nakazato A. Yasuhara A, et al. Among authors: sakagami k. Bioorg Med Chem. 2006 May 15;14(10):3405-20. doi: 10.1016/j.bmc.2005.12.061. Epub 2006 Jan 20. Bioorg Med Chem. 2006. PMID: 16431115

6

Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): a potent and orally active group II mGluR antagonist with antidepressant-like potential.

Yasuhara A, Nakamura M, Sakagami K, Shimazaki T, Yoshikawa R, Chaki S, Ohta H, Nakazato A. Yasuhara A, et al. Among authors: sakagami k. Bioorg Med Chem. 2006 Jun 15;14(12):4193-207. doi: 10.1016/j.bmc.2006.01.060. Epub 2006 Feb 17. Bioorg Med Chem. 2006. PMID: 16487713

7

Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.

Nakazato A, Kumagai T, Sakagami K, Yoshikawa R, Suzuki Y, Chaki S, Ito H, Taguchi T, Nakanishi S, Okuyama S. Nakazato A, et al. Among authors: sakagami k. J Med Chem. 2000 Dec 14;43(25):4893-909. doi: 10.1021/jm000346k. J Med Chem. 2000. PMID: 11123999

8

Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist.

Sakagami K, Yasuhara A, Chaki S, Yoshikawa R, Kawakita Y, Saito A, Taguchi T, Nakazato A. Sakagami K, et al. Bioorg Med Chem. 2008 Apr 15;16(8):4359-66. doi: 10.1016/j.bmc.2008.02.066. Epub 2008 Feb 26. Bioorg Med Chem. 2008. PMID: 18348906

9

Synthetic cephalosporins. VII. Synthesis and antibacterial activity of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(3-(3-hydroxy-4-pyridon-1-yl)-3- carboxypropoxyimino)acetamido]-3-(1,2,3-thiadiazol-5-yl)-thiomethyl-3- cephem-4-carboxylic acid and its related compounds.

Sakagami K, Iwamatsu K, Atsumi K, Hatanaka M. Sakagami K, et al. Chem Pharm Bull (Tokyo). 1990 Dec;38(12):3476-9. doi: 10.1248/cpb.38.3476. Chem Pharm Bull (Tokyo). 1990. PMID: 2092946

10

Synthesis and oral activity of pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3(Z)- (4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (ME1207) and its related compound.

Sakagami K, Atsumi K, Yamamoto Y, Tamura A, Yoshida T, Nishihata K, Fukatsu S. Sakagami K, et al. Chem Pharm Bull (Tokyo). 1991 Sep;39(9):2433-6. doi: 10.1248/cpb.39.2433. Chem Pharm Bull (Tokyo). 1991. PMID: 1804557

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