Stewart KD - Search Results

1

Thienopyridine urea inhibitors of KDR kinase.

Heyman HR, Frey RR, Bousquet PF, Cunha GA, Moskey MD, Ahmed AA, Soni NB, Marcotte PA, Pease LJ, Glaser KB, Yates M, Bouska JJ, Albert DH, Black-Schaefer CL, Dandliker PJ, Stewart KD, Rafferty P, Davidsen SK, Michaelides MR, Curtin ML. Heyman HR, et al. Among authors: stewart kd. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1246-9. doi: 10.1016/j.bmcl.2006.12.015. Epub 2006 Dec 9. Bioorg Med Chem Lett. 2007. PMID: 17188869

2

A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.

Sham HL, Zhao C, Stewart KD, Betebenner DA, Lin S, Park CH, Kong XP, Rosenbrook W Jr, Herrin T, Madigan D, Vasavanonda S, Lyons N, Molla A, Saldivar A, Marsh KC, McDonald E, Wideburg NE, Denissen JF, Robins T, Kempf DJ, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: stewart kd. J Med Chem. 1996 Jan 19;39(2):392-7. doi: 10.1021/jm9507183. J Med Chem. 1996. PMID: 8558507

3

Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.

Stewart KD, Loren S, Frey L, Otis E, Klinghofer V, Hulkower KI. Stewart KD, et al. Bioorg Med Chem Lett. 1998 Mar 3;8(5):529-34. doi: 10.1016/s0960-894x(98)00068-7. Bioorg Med Chem Lett. 1998. PMID: 9871612

4

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

Wang GT, Chen Y, Wang S, Gentles R, Sowin T, Kati W, Muchmore S, Giranda V, Stewart K, Sham H, Kempf D, Laver WG. Wang GT, et al. J Med Chem. 2001 Apr 12;44(8):1192-201. doi: 10.1021/jm000468c. J Med Chem. 2001. PMID: 11312919

5

Candida proteases and their inhibition: prospects for antifungal therapy.

Stewart K, Abad-Zapatero C. Stewart K, et al. Curr Med Chem. 2001 Jul;8(8):941-8. doi: 10.2174/0929867013372698. Curr Med Chem. 2001. PMID: 11375761 Review.

6

X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease.

Stoll V, Qin W, Stewart KD, Jakob C, Park C, Walter K, Simmer RL, Helfrich R, Bussiere D, Kao J, Kempf D, Sham HL, Norbeck DW. Stoll V, et al. Among authors: stewart kd. Bioorg Med Chem. 2002 Aug;10(8):2803-6. doi: 10.1016/s0968-0896(02)00051-2. Bioorg Med Chem. 2002. PMID: 12057670

7

Transforming growth factor beta mimetics: discovery of 7-[4-(4-cyanophenyl)phenoxy]-heptanohydroxamic acid, a biaryl hydroxamate inhibitor of histone deacetylase.

Glaser KB, Li J, Aakre ME, Morgan DW, Sheppard G, Stewart KD, Pollock J, Lee P, O'Connor CZ, Anderson SN, Mussatto DJ, Wegner CW, Moses HL. Glaser KB, et al. Among authors: stewart kd. Mol Cancer Ther. 2002 Aug;1(10):759-68. Mol Cancer Ther. 2002. PMID: 12492108

8

Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series.

Stoll V, Stewart KD, Maring CJ, Muchmore S, Giranda V, Gu YG, Wang G, Chen Y, Sun M, Zhao C, Kennedy AL, Madigan DL, Xu Y, Saldivar A, Kati W, Laver G, Sowin T, Sham HL, Greer J, Kempf D. Stoll V, et al. Among authors: stewart kd. Biochemistry. 2003 Jan 28;42(3):718-27. doi: 10.1021/bi0205449. Biochemistry. 2003. PMID: 12534284

9

Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.

Wendt MD, Rockway TW, Geyer A, McClellan W, Weitzberg M, Zhao X, Mantei R, Nienaber VL, Stewart K, Klinghofer V, Giranda VL. Wendt MD, et al. J Med Chem. 2004 Jan 15;47(2):303-24. doi: 10.1021/jm0300072. J Med Chem. 2004. PMID: 14711304

10

Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.

Wendt MD, Geyer A, McClellan WJ, Rockway TW, Weitzberg M, Zhao X, Mantei R, Stewart K, Nienaber V, Klinghofer V, Giranda VL. Wendt MD, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3063-8. doi: 10.1016/j.bmcl.2004.04.030. Bioorg Med Chem Lett. 2004. PMID: 15149645

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