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Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR.
Bruzzone S, Dodoni G, Kaludercic N, Basile G, Millo E, De Flora A, Di Lisa F, Zocchi E. Bruzzone S, et al. Among authors: de flora a. J Biol Chem. 2007 Feb 16;282(7):5045-5052. doi: 10.1074/jbc.M609802200. Epub 2006 Dec 8. J Biol Chem. 2007. PMID: 17158448 Free article.
ADP-ribosyl cyclases were previously shown to produce three new adenine dinucleotides, P1,P2 diadenosine 5'-diphosphate (Ap2A) and two isomers thereof (P18 and P24), from cyclic ADP-ribose (cADPR) and adenine (Basile, G., Taglialatela-Scafati, O., Damonte, G., Armirotti, A …
ADP-ribosyl cyclases were previously shown to produce three new adenine dinucleotides, P1,P2 diadenosine 5'-diphosphate (Ap2A) and two isome …
ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells.
Basile G, Taglialatela-Scafati O, Damonte G, Armirotti A, Bruzzone S, Guida L, Franco L, Usai C, Fattorusso E, De Flora A, Zocchi E. Basile G, et al. Among authors: de flora a. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14509-14. doi: 10.1073/pnas.0503691102. Epub 2005 Sep 19. Proc Natl Acad Sci U S A. 2005. PMID: 16172408 Free PMC article.
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.
Moreschi I, Bruzzone S, Melone L, De Flora A, Zocchi E. Moreschi I, et al. Among authors: de flora a. Biochem Biophys Res Commun. 2006 Jun 30;345(2):573-80. doi: 10.1016/j.bbrc.2006.04.096. Epub 2006 Apr 27. Biochem Biophys Res Commun. 2006. PMID: 16690024
Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.
Bruzzone S, Basile G, Chothi MP, Nobbio L, Usai C, Jacchetti E, Schenone A, Guse AH, Di Virgilio F, De Flora A, Zocchi E. Bruzzone S, et al. Among authors: de flora a. J Biol Chem. 2010 Jul 2;285(27):21165-74. doi: 10.1074/jbc.M109.097964. Epub 2010 May 3. J Biol Chem. 2010. PMID: 20439466 Free PMC article.
P18 and P24 are characterized by an unusual N-glycosidic linkage in one of the adenylic mononucleotides (Basile, G., Taglialatela-Scafati, O., Damonte, G., Armirotti, A., Bruzzone, S., Guida, L., Franco, L., Usai, C., Fattorusso, E., De Flora, A., and …
P18 and P24 are characterized by an unusual N-glycosidic linkage in one of the adenylic mononucleotides (Basile, G., Taglialatela-Scafati, O …
214 results