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Page 1
DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.
Gilbert KM, Boos TL, Dersch CM, Greiner E, Jacobson AE, Lewis D, Matecka D, Prisinzano TE, Zhang Y, Rothman RB, Rice KC, Venanzi CA. Gilbert KM, et al. Among authors: rothman rb. Bioorg Med Chem. 2007 Jan 15;15(2):1146-59. doi: 10.1016/j.bmc.2006.09.070. Epub 2006 Oct 1. Bioorg Med Chem. 2007. PMID: 17127069 Free PMC article.
Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.
Hsin LW, Dersch CM, Baumann MH, Stafford D, Glowa JR, Rothman RB, Jacobson AE, Rice KC. Hsin LW, et al. Among authors: rothman rb. J Med Chem. 2002 Mar 14;45(6):1321-9. doi: 10.1021/jm010430f. J Med Chem. 2002. PMID: 11882001
Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.
Lewis D, Zhang Y, Prisinzano T, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Lewis D, et al. Among authors: rothman rb. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1385-9. doi: 10.1016/s0960-894x(03)00108-2. Bioorg Med Chem Lett. 2003. PMID: 12657288
Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter.
Boos TL, Greiner E, Calhoun WJ, Prisinzano TE, Nightingale B, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Boos TL, et al. Among authors: rothman rb. Bioorg Med Chem. 2006 Jun 1;14(11):3967-73. doi: 10.1016/j.bmc.2006.01.065. Epub 2006 Mar 24. Bioorg Med Chem. 2006. PMID: 16563775
Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters.
Hsin LW, Chang LT, Rothman RB, Dersch CM, Jacobson AE, Rice KC. Hsin LW, et al. Among authors: rothman rb. J Med Chem. 2008 May 8;51(9):2795-806. doi: 10.1021/jm701270n. Epub 2008 Apr 5. J Med Chem. 2008. PMID: 18393401 Free PMC article.
421 results