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Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness.
Tsang SH, Woodruff ML, Jun L, Mahajan V, Yamashita CK, Pedersen R, Lin CS, Goff SP, Rosenberg T, Larsen M, Farber DB, Nusinowitz S. Tsang SH, et al. Among authors: woodruff ml. Hum Mutat. 2007 Mar;28(3):243-54. doi: 10.1002/humu.20425. Hum Mutat. 2007. PMID: 17044014 Free PMC article.
Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q).
Davis RJ, Tosi J, Janisch KM, Kasanuki JM, Wang NK, Kong J, Tsui I, Cilluffo M, Woodruff ML, Fain GL, Lin CS, Tsang SH. Davis RJ, et al. Among authors: woodruff ml. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):5067-76. doi: 10.1167/iovs.07-1422. Epub 2008 Jul 24. Invest Ophthalmol Vis Sci. 2008. PMID: 18658088 Free PMC article.
87 results