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Immunization of Rhesus monkeys with a SialylTn-mAb17-1A conjugate vaccine co-formulated with QS-21 induces a temporary systemic cytokine release and NK cytotoxicity against tumor cells.
Kircheis R, Siegl P, Grunt S, Halanek N, Loibner H, Mudde GC, Nechansky A. Kircheis R, et al. Among authors: loibner h. Cancer Immunol Immunother. 2007 Jun;56(6):863-73. doi: 10.1007/s00262-006-0231-x. Epub 2006 Sep 29. Cancer Immunol Immunother. 2007. PMID: 17009044 Free PMC article.
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