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Inhibition of polyadenylation reduces inflammatory gene induction.
Kondrashov A, Meijer HA, Barthet-Barateig A, Parker HN, Khurshid A, Tessier S, Sicard M, Knox AJ, Pang L, De Moor CH. Kondrashov A, et al. RNA. 2012 Dec;18(12):2236-50. doi: 10.1261/rna.032391.112. Epub 2012 Nov 1. RNA. 2012. PMID: 23118416 Free PMC article.
Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.
Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, Stoneley M, Kong YW, Cotes JA, Smith GC, Wek R, Hayes C, Gant TW, Spriggs KA, Bushell M, Willis AE. Powley IR, et al. Among authors: kondrashov a. Genes Dev. 2009 May 15;23(10):1207-20. doi: 10.1101/gad.516509. Genes Dev. 2009. PMID: 19451221 Free PMC article.
A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.
Somers J, Wilson LA, Kilday JP, Horvilleur E, Cannell IG, Pöyry TA, Cobbold LC, Kondrashov A, Knight JR, Puget S, Grill J, Grundy RG, Bushell M, Willis AE. Somers J, et al. Among authors: kondrashov a. Genes Dev. 2015 Sep 15;29(18):1891-6. doi: 10.1101/gad.261867.115. Epub 2015 Sep 3. Genes Dev. 2015. PMID: 26338418 Free PMC article.
Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.
Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE. Denning C, et al. Among authors: kondrashov a. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1728-48. doi: 10.1016/j.bbamcr.2015.10.014. Epub 2015 Oct 31. Biochim Biophys Acta. 2016. PMID: 26524115 Free PMC article.
Co-ordinated regulation of translation following DNA damage.
Kondrashov AV, Spriggs KA, Bushell M, Willis AE. Kondrashov AV, et al. Cell Cycle. 2009 Oct 1;8(19):3067-8. doi: 10.4161/cc.8.19.9467. Epub 2009 Oct 8. Cell Cycle. 2009. PMID: 19755844 No abstract available.
CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes.
Kondrashov A, Mohd Yusof NAN, Hasan A, Goulding J, Kodagoda T, Hoang DM, Vo NTN, Melarangi T, Dolatshad N, Gorelik J, Hill SJ, Harding SE, Denning C. Kondrashov A, et al. Mol Ther Methods Clin Dev. 2020 Oct 27;20:39-53. doi: 10.1016/j.omtm.2020.10.019. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33335946 Free PMC article.
181 results