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5'-halogenated analogs of oxymorphindole.
Metcalf MD, Coop A. Metcalf MD, et al. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5916-7. doi: 10.1016/j.bmcl.2007.07.098. Epub 2007 Aug 23. Bioorg Med Chem Lett. 2007. PMID: 17826993 Free PMC article.
Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.
Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Zhang X, et al. Among authors: metcalf md. FASEB J. 2019 Aug;33(8):9577-9587. doi: 10.1096/fj.201900173RRR. Epub 2019 Jun 4. FASEB J. 2019. PMID: 31162938 Free PMC article.
This is the first report showing enantioselective modulation of the innate immune TLR signaling.-Zhang, X., Peng, Y., Grace, P. M., Metcalf, M. D., Kwilasz, A. J., Wang, Y., Zhang, T., Wu, S., Selfridge, B. R., Portoghese, P. S., Rice, K. C., Watkins, L. R., …
This is the first report showing enantioselective modulation of the innate immune TLR signaling.-Zhang, X., Peng, Y., Grace, P. M., …
283 results