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Page 1
Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration.
Kermorvant-Duchemin E, Sennlaub F, Sirinyan M, Brault S, Andelfinger G, Kooli A, Germain S, Ong H, d'Orleans-Juste P, Gobeil F Jr, Zhu T, Boisvert C, Hardy P, Jain K, Falck JR, Balazy M, Chemtob S. Kermorvant-Duchemin E, et al. Among authors: sirinyan m. Nat Med. 2005 Dec;11(12):1339-45. doi: 10.1038/nm1336. Epub 2005 Nov 27. Nat Med. 2005. PMID: 16311602 Free PMC article.
Hypercapnia prevents neovascularization via nitrative stress.
Checchin D, Sennlaub F, Sirinyan M, Brault S, Zhu T, Kermorvant-Duchemin E, Hardy P, Balazy M, Chemtob S. Checchin D, et al. Among authors: sirinyan m. Free Radic Biol Med. 2006 Feb 1;40(3):543-53. doi: 10.1016/j.freeradbiomed.2005.09.016. Epub 2005 Nov 14. Free Radic Biol Med. 2006. PMID: 16443170
Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-alpha and consecutively Tie2 dependent.
Zhu T, Sennlaub F, Beauchamp MH, Fan L, Joyal JS, Checchin D, Nim S, Lachapelle P, Sirinyan M, Hou X, Bossolasco M, Rivard GE, Heveker N, Chemtob S. Zhu T, et al. Among authors: sirinyan m. Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):744-50. doi: 10.1161/01.ATV.0000205591.88522.d4. Epub 2006 Jan 26. Arterioscler Thromb Vasc Biol. 2006. PMID: 16439712
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.
Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S. Sapieha P, et al. Among authors: sirinyan m. Nat Med. 2008 Oct;14(10):1067-76. doi: 10.1038/nm.1873. Epub 2008 Oct 5. Nat Med. 2008. PMID: 18836459
CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.
Combadière C, Feumi C, Raoul W, Keller N, Rodéro M, Pézard A, Lavalette S, Houssier M, Jonet L, Picard E, Debré P, Sirinyan M, Deterre P, Ferroukhi T, Cohen SY, Chauvaud D, Jeanny JC, Chemtob S, Behar-Cohen F, Sennlaub F. Combadière C, et al. Among authors: sirinyan m. J Clin Invest. 2007 Oct;117(10):2920-8. doi: 10.1172/JCI31692. J Clin Invest. 2007. PMID: 17909628 Free PMC article.