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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.
Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, Labaer J, Rochet JC, Bonini NM, Lindquist S. Cooper AA, et al. Among authors: lindquist s. Science. 2006 Jul 21;313(5785):324-8. doi: 10.1126/science.1129462. Epub 2006 Jun 22. Science. 2006. PMID: 16794039 Free PMC article.
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet JC, Lindquist S. Su LJ, et al. Among authors: lindquist s. Dis Model Mech. 2010 Mar-Apr;3(3-4):194-208. doi: 10.1242/dmm.004267. Epub 2009 Dec 28. Dis Model Mech. 2010. PMID: 20038714 Free PMC article.
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.
Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. Gitler AD, et al. Among authors: lindquist s. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):145-50. doi: 10.1073/pnas.0710685105. Epub 2007 Dec 27. Proc Natl Acad Sci U S A. 2008. PMID: 18162536 Free PMC article.
Calcineurin determines toxic versus beneficial responses to α-synuclein.
Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Ben-Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, Lindquist S. Caraveo G, et al. Among authors: lindquist s. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3544-52. doi: 10.1073/pnas.1413201111. Epub 2014 Aug 13. Proc Natl Acad Sci U S A. 2014. PMID: 25122673 Free PMC article.
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.
Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, Olofsson A, DeJager PL, Tanzi RE, Caldwell KA, Caldwell GA, Lindquist S. Treusch S, et al. Among authors: lindquist s. Science. 2011 Dec 2;334(6060):1241-5. doi: 10.1126/science.1213210. Epub 2011 Oct 27. Science. 2011. PMID: 22033521 Free PMC article.
464 results