Zhang X - Search Results

1

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.

Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J. Zhang X, et al. Cell. 2006 Jun 16;125(6):1137-49. doi: 10.1016/j.cell.2006.05.013. Cell. 2006. PMID: 16777603 Free article.

2

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J. Zhang X, et al. Nature. 2007 Nov 29;450(7170):741-4. doi: 10.1038/nature05998. Nature. 2007. PMID: 18046415 Free PMC article.

3

The ErbB kinase domain: structural perspectives into kinase activation and inhibition.

Bose R, Zhang X. Bose R, et al. Among authors: zhang x. Exp Cell Res. 2009 Feb 15;315(4):649-58. doi: 10.1016/j.yexcr.2008.07.031. Epub 2008 Aug 15. Exp Cell Res. 2009. PMID: 18761339 Free PMC article. Review.

4

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.

Jura N, Endres NF, Engel K, Deindl S, Das R, Lamers MH, Wemmer DE, Zhang X, Kuriyan J. Jura N, et al. Among authors: zhang x. Cell. 2009 Jun 26;137(7):1293-307. doi: 10.1016/j.cell.2009.04.025. Cell. 2009. PMID: 19563760 Free PMC article.

5

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.

Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J. Jura N, et al. Among authors: zhang x. Mol Cell. 2011 Apr 8;42(1):9-22. doi: 10.1016/j.molcel.2011.03.004. Mol Cell. 2011. PMID: 21474065 Free PMC article. Review.

6

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization.

Shan Y, Eastwood MP, Zhang X, Kim ET, Arkhipov A, Dror RO, Jumper J, Kuriyan J, Shaw DE. Shan Y, et al. Among authors: zhang x. Cell. 2012 May 11;149(4):860-70. doi: 10.1016/j.cell.2012.02.063. Cell. 2012. PMID: 22579287 Free article.

7

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop.

Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ. Zhang X, et al. Cell Rep. 2014 Feb 13;6(3):421-30. doi: 10.1016/j.celrep.2014.01.003. Epub 2014 Jan 23. Cell Rep. 2014. PMID: 24462292 Free PMC article.

8

Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.

Hu L, Zhang Y, Guo L, Zhong H, Xie L, Zhou J, Liao C, Yao H, Fang J, Liu H, Zhang C, Zhang H, Zhu X, Luo M, von Kriegsheim A, Li B, Luo W, Zhang X, Chen X, Mendell JT, Xu L, Kapur P, Baldwin AS, Brugarolas J, Zhang Q. Hu L, et al. Among authors: zhang c, zhang q, zhang h, zhang x, zhang y. Mol Cell. 2024 Feb 15;84(4):776-790.e5. doi: 10.1016/j.molcel.2023.12.010. Epub 2024 Jan 10. Mol Cell. 2024. PMID: 38211588

9

Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.

Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ. Zhang X, et al. Mol Cell. 2013 Jul 25;51(2):226-35. doi: 10.1016/j.molcel.2013.05.022. Epub 2013 Jun 6. Mol Cell. 2013. PMID: 23747010 Free PMC article.

10

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.

Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L. Wu X, et al. Among authors: zhang ls, zhang x. Nat Cell Biol. 2017 Oct;19(10):1226-1236. doi: 10.1038/ncb3616. Epub 2017 Sep 25. Nat Cell Biol. 2017. PMID: 28945232 Free PMC article.

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