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A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide.
Way D, Smith S, Sivendran S, Chie L, Kanovsky M, Brandt-Rauf PW, Chung DL, Michl J, Pincus MR. Way D, et al. Among authors: pincus mr. Cancer Chemother Pharmacol. 2002 Jun;49(6):429-37. doi: 10.1007/s00280-002-0432-8. Epub 2002 Mar 13. Cancer Chemother Pharmacol. 2002. PMID: 12107546
Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth.
Kanovsky M, Michl J, Botzolaki G, Morin J, Kovac C, Chung DL, Chie L, Friedman FK, Pincus MR. Kanovsky M, et al. Among authors: pincus mr. Cancer Chemother Pharmacol. 2003 Sep;52(3):202-8. doi: 10.1007/s00280-003-0639-3. Epub 2003 May 29. Cancer Chemother Pharmacol. 2003. PMID: 12783204
The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells.
Bowne WB, Sookraj KA, Vishnevetsky M, Adler V, Sarafraz-Yazdi E, Lou S, Koenke J, Shteyler V, Ikram K, Harding M, Bluth MH, Ng M, Brandt-Rauf PW, Hannan R, Bradu S, Zenilman ME, Michl J, Pincus MR. Bowne WB, et al. Among authors: pincus mr. Ann Surg Oncol. 2008 Dec;15(12):3588-600. doi: 10.1245/s10434-008-0147-0. Epub 2008 Oct 18. Ann Surg Oncol. 2008. PMID: 18931881
Computational protein chemistry of p53 and p53 peptides.
Brandt-Rauf PW, Rosal RV, Fine RL, Pincus MR. Brandt-Rauf PW, et al. Among authors: pincus mr. Front Biosci. 2004 Sep 1;9:2778-87. doi: 10.2741/1435. Front Biosci. 2004. PMID: 15353313 Review.
206 results