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A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide.
Way D, Smith S, Sivendran S, Chie L, Kanovsky M, Brandt-Rauf PW, Chung DL, Michl J, Pincus MR. Way D, et al. Among authors: michl j. Cancer Chemother Pharmacol. 2002 Jun;49(6):429-37. doi: 10.1007/s00280-002-0432-8. Epub 2002 Mar 13. Cancer Chemother Pharmacol. 2002. PMID: 12107546
Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth.
Kanovsky M, Michl J, Botzolaki G, Morin J, Kovac C, Chung DL, Chie L, Friedman FK, Pincus MR. Kanovsky M, et al. Among authors: michl j. Cancer Chemother Pharmacol. 2003 Sep;52(3):202-8. doi: 10.1007/s00280-003-0639-3. Epub 2003 May 29. Cancer Chemother Pharmacol. 2003. PMID: 12783204
The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells.
Bowne WB, Sookraj KA, Vishnevetsky M, Adler V, Sarafraz-Yazdi E, Lou S, Koenke J, Shteyler V, Ikram K, Harding M, Bluth MH, Ng M, Brandt-Rauf PW, Hannan R, Bradu S, Zenilman ME, Michl J, Pincus MR. Bowne WB, et al. Among authors: michl j. Ann Surg Oncol. 2008 Dec;15(12):3588-600. doi: 10.1245/s10434-008-0147-0. Epub 2008 Oct 18. Ann Surg Oncol. 2008. PMID: 18931881
Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.
Sarafraz-Yazdi E, Bowne WB, Adler V, Sookraj KA, Wu V, Shteyler V, Patel H, Oxbury W, Brandt-Rauf P, Zenilman ME, Michl J, Pincus MR. Sarafraz-Yazdi E, et al. Among authors: michl j. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1918-23. doi: 10.1073/pnas.0909364107. Epub 2010 Jan 11. Proc Natl Acad Sci U S A. 2010. PMID: 20080680 Free PMC article.
Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells.
Kanovsky M, Raffo A, Drew L, Rosal R, Do T, Friedman FK, Rubinstein P, Visser J, Robinson R, Brandt-Rauf PW, Michl J, Fine RL, Pincus MR. Kanovsky M, et al. Among authors: michl j. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12438-43. doi: 10.1073/pnas.211280698. Epub 2001 Oct 16. Proc Natl Acad Sci U S A. 2001. PMID: 11606716 Free PMC article.
290 results