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The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournès B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A. Dubois MJ, et al. Among authors: siminovitch ka. Nat Med. 2006 May;12(5):549-56. doi: 10.1038/nm1397. Epub 2006 Apr 16. Nat Med. 2006. PMID: 16617349
Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ.
Xu E, Forest MP, Schwab M, Avramoglu RK, St-Amand E, Caron AZ, Bellmann K, Shum M, Voisin G, Paquet M, Montoudis A, Lévy E, Siminovitch KA, Neel BG, Beauchemin N, Marette A. Xu E, et al. Among authors: siminovitch ka. Hepatology. 2014 May;59(5):1803-15. doi: 10.1002/hep.26957. Epub 2014 Apr 1. Hepatology. 2014. PMID: 24327268
Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.
Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, Marsden PA, Mustelin T, Siminovitch KA, Downey GP. Wang Y, et al. Among authors: siminovitch ka. J Exp Med. 2005 Dec 5;202(11):1587-97. doi: 10.1084/jem.20051108. J Exp Med. 2005. PMID: 16330817 Free PMC article.
236 results