Buchstaller HP - Search Results

1

Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor.

Buchstaller HP, Siebert CD, Steinmetz R, Frank I, Berger ML, Gottschlich R, Leibrock J, Krug M, Steinhilber D, Noe CR. Buchstaller HP, et al. J Med Chem. 2006 Feb 9;49(3):864-71. doi: 10.1021/jm0503493. J Med Chem. 2006. PMID: 16451052

2

Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors.

Buchstaller HP, Burgdorf L, Finsinger D, Stieber F, Sirrenberg C, Amendt C, Grell M, Zenke F, Krier M. Buchstaller HP, et al. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2264-9. doi: 10.1016/j.bmcl.2011.02.108. Epub 2011 Mar 1. Bioorg Med Chem Lett. 2011. PMID: 21420298

3

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.

Schuetz DA, Richter L, Amaral M, Grandits M, Grädler U, Musil D, Buchstaller HP, Eggenweiler HM, Frech M, Ecker GF. Schuetz DA, et al. Among authors: buchstaller hp. J Med Chem. 2018 May 24;61(10):4397-4411. doi: 10.1021/acs.jmedchem.8b00080. Epub 2018 May 10. J Med Chem. 2018. PMID: 29701469

4

Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity.

Buchstaller HP, Anlauf U, Dorsch D, Kuhn D, Lehmann M, Leuthner B, Musil D, Radtki D, Ritzert C, Rohdich F, Schneider R, Esdar C. Buchstaller HP, et al. J Med Chem. 2019 Sep 12;62(17):7897-7909. doi: 10.1021/acs.jmedchem.9b00656. Epub 2019 Aug 20. J Med Chem. 2019. PMID: 31381853

5

Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.

Buchstaller HP, Anlauf U, Dorsch D, Kögler S, Kuhn D, Lehmann M, Leuthner B, Lodholz S, Musil D, Radtki D, Rettig C, Ritzert C, Rohdich F, Schneider R, Wegener A, Weigt S, Wilkinson K, Esdar C. Buchstaller HP, et al. J Med Chem. 2021 Jul 22;64(14):10371-10392. doi: 10.1021/acs.jmedchem.1c00800. Epub 2021 Jul 13. J Med Chem. 2021. PMID: 34255518

6

The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.

Schiemann K, Finsinger D, Zenke F, Amendt C, Knöchel T, Bruge D, Buchstaller HP, Emde U, Stähle W, Anzali S. Schiemann K, et al. Among authors: buchstaller hp. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5. doi: 10.1016/j.bmcl.2010.01.110. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20149654

7

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.

Buchstaller HP, Eggenweiler HM, Sirrenberg C, Grädler U, Musil D, Hoppe E, Zimmermann A, Schwartz H, März J, Bomke J, Wegener A, Wolf M. Buchstaller HP, et al. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4396-403. doi: 10.1016/j.bmcl.2012.04.121. Epub 2012 May 5. Bioorg Med Chem Lett. 2012. PMID: 22632933

8

Discovery of novel 7-azaindoles as PDK1 inhibitors.

Wucherer-Plietker M, Merkul E, Müller TJJ, Esdar C, Knöchel T, Heinrich T, Buchstaller HP, Greiner H, Dorsch D, Finsinger D, Calderini M, Bruge D, Grädler U. Wucherer-Plietker M, et al. Among authors: buchstaller hp. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3073-3080. doi: 10.1016/j.bmcl.2016.05.005. Epub 2016 May 4. Bioorg Med Chem Lett. 2016. PMID: 27217002

9

Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates.

Heinrich T, Buchstaller HP, Cezanne B, Rohdich F, Bomke J, Friese-Hamim M, Krier M, Knöchel T, Musil D, Leuthner B, Zenke F. Heinrich T, et al. Among authors: buchstaller hp. Bioorg Med Chem Lett. 2017 Feb 1;27(3):551-556. doi: 10.1016/j.bmcl.2016.12.019. Epub 2016 Dec 8. Bioorg Med Chem Lett. 2017. PMID: 27998678

10

Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors.

Blum A, Dorsch D, Linde N, Brandstetter S, Buchstaller HP, Busch M, Glaser N, Grädler U, Ruff A, Petersson C, Schieferstein H, Sherbetjian E, Esdar C. Blum A, et al. Among authors: buchstaller hp. J Med Chem. 2023 Feb 23;66(4):2386-2395. doi: 10.1021/acs.jmedchem.2c00851. Epub 2023 Feb 2. J Med Chem. 2023. PMID: 36728508

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