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Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways.
Kubota N, Terauchi Y, Kubota T, Kumagai H, Itoh S, Satoh H, Yano W, Ogata H, Tokuyama K, Takamoto I, Mineyama T, Ishikawa M, Moroi M, Sugi K, Yamauchi T, Ueki K, Tobe K, Noda T, Nagai R, Kadowaki T. Kubota N, et al. Among authors: nagai r. J Biol Chem. 2006 Mar 31;281(13):8748-55. doi: 10.1074/jbc.M505649200. Epub 2006 Jan 23. J Biol Chem. 2006. PMID: 16431926 Free article.
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.
Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R, Kadowaki T. Yamauchi T, et al. Among authors: nagai r. J Biol Chem. 2003 Jan 24;278(4):2461-8. doi: 10.1074/jbc.M209033200. Epub 2002 Nov 12. J Biol Chem. 2003. PMID: 12431986 Free article.
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
Suzuki R, Tobe K, Terauchi Y, Komeda K, Kubota N, Eto K, Yamauchi T, Azuma K, Kaneto H, Taguchi T, Koga T, German MS, Watada H, Kawamori R, Wright CV, Kajimoto Y, Kimura S, Nagai R, Kadowaki T. Suzuki R, et al. Among authors: nagai r. J Biol Chem. 2003 Oct 31;278(44):43691-8. doi: 10.1074/jbc.M307004200. Epub 2003 Jul 16. J Biol Chem. 2003. PMID: 12869553 Free article.
Molecular mechanism of insulin resistance and obesity.
Kadowaki T, Hara K, Yamauchi T, Terauchi Y, Tobe K, Nagai R. Kadowaki T, et al. Among authors: nagai r. Exp Biol Med (Maywood). 2003 Nov;228(10):1111-7. doi: 10.1177/153537020322801003. Exp Biol Med (Maywood). 2003. PMID: 14610248 Review.
Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice.
Suzuki R, Tobe K, Aoyama M, Inoue A, Sakamoto K, Yamauchi T, Kamon J, Kubota N, Terauchi Y, Yoshimatsu H, Matsuhisa M, Nagasaka S, Ogata H, Tokuyama K, Nagai R, Kadowaki T. Suzuki R, et al. Among authors: nagai r. J Biol Chem. 2004 Jun 11;279(24):25039-49. doi: 10.1074/jbc.M311956200. Epub 2004 Mar 17. J Biol Chem. 2004. PMID: 15028732 Free article.
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.
Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T. Tsuchida A, et al. Among authors: nagai r. J Biol Chem. 2004 Jul 16;279(29):30817-22. doi: 10.1074/jbc.M402367200. Epub 2004 Apr 29. J Biol Chem. 2004. PMID: 15123605 Free article.
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance.
Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, Ohtsuka-Kowatari N, Kumagai K, Sakamoto K, Kobayashi M, Yamauchi T, Ueki K, Oishi Y, Nishimura S, Manabe I, Hashimoto H, Ohnishi Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Nagai R, Kadowaki T. Kamei N, et al. Among authors: nagai r. J Biol Chem. 2006 Sep 8;281(36):26602-14. doi: 10.1074/jbc.M601284200. Epub 2006 Jun 29. J Biol Chem. 2006. PMID: 16809344 Free article.
1,779 results