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Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways.
Kubota N, Terauchi Y, Kubota T, Kumagai H, Itoh S, Satoh H, Yano W, Ogata H, Tokuyama K, Takamoto I, Mineyama T, Ishikawa M, Moroi M, Sugi K, Yamauchi T, Ueki K, Tobe K, Noda T, Nagai R, Kadowaki T. Kubota N, et al. Among authors: moroi m. J Biol Chem. 2006 Mar 31;281(13):8748-55. doi: 10.1074/jbc.M505649200. Epub 2006 Jan 23. J Biol Chem. 2006. PMID: 16431926 Free article.
Disruption of adiponectin causes insulin resistance and neointimal formation.
Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, Eto K, Yamashita T, Kamon J, Satoh H, Yano W, Froguel P, Nagai R, Kimura S, Kadowaki T, Noda T. Kubota N, et al. Among authors: moroi m. J Biol Chem. 2002 Jul 19;277(29):25863-6. doi: 10.1074/jbc.C200251200. Epub 2002 May 24. J Biol Chem. 2002. PMID: 12032136 Free article.
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
Kubota N, Terauchi Y, Tobe K, Yano W, Suzuki R, Ueki K, Takamoto I, Satoh H, Maki T, Kubota T, Moroi M, Okada-Iwabu M, Ezaki O, Nagai R, Ueta Y, Kadowaki T, Noda T. Kubota N, et al. Among authors: moroi m. J Clin Invest. 2004 Oct;114(7):917-27. doi: 10.1172/JCI21484. J Clin Invest. 2004. PMID: 15467830 Free PMC article.
270 results