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Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats.
Kamble SH, Obeng S, León F, Restrepo LF, King TI, Berthold EC, Kanumuri SRR, Gamez-Jimenez LR, Pallares VLC, Patel A, Ho NP, Hampson A, McCurdy CR, McMahon LR, Wilkerson JL, Sharma A, Hiranita T. Kamble SH, et al. Among authors: restrepo lf. J Pharmacol Exp Ther. 2023 Jun;385(3):180-192. doi: 10.1124/jpet.122.001525. Epub 2023 Apr 5. J Pharmacol Exp Ther. 2023. PMID: 37019472 Free PMC article.
Interactive Effects of µ-Opioid and Adrenergic-α 2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine.
Obeng S, Leon F, Patel A, Zuarth Gonzalez JD, Chaves Da Silva L, Restrepo LF, Gamez-Jimenez LR, Ho NP, Guerrero Calvache MP, Pallares VLC, Helmes JA, Shiomitsu SK, Soto PL, McCurdy CR, McMahon LR, Wilkerson JL, Hiranita T. Obeng S, et al. Among authors: restrepo lf. J Pharmacol Exp Ther. 2022 Dec;383(3):182-198. doi: 10.1124/jpet.122.001192. Epub 2022 Sep 24. J Pharmacol Exp Ther. 2022. PMID: 36153006 Free PMC article.
The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study.
Berthold EC, Kamble SH, Raju KS, Kuntz MA, Senetra AS, Mottinelli M, León F, Restrepo LF, Patel A, Ho NP, Hiranita T, Sharma A, McMahon LR, McCurdy CR. Berthold EC, et al. Among authors: restrepo lf. Drug Metab Dispos. 2022 Feb;50(2):158-167. doi: 10.1124/dmd.121.000640. Epub 2021 Nov 10. Drug Metab Dispos. 2022. PMID: 34759012 Free PMC article.
19 results