Lehman-McKeeman LD - Search Results

1

Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine.

Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Deng X, Maddox JF, Ganey PE, Roth RA. Luyendyk JP, et al. J Pharmacol Exp Ther. 2006 May;317(2):635-43. doi: 10.1124/jpet.105.096305. Epub 2006 Jan 9. J Pharmacol Exp Ther. 2006. PMID: 16401727

2

Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.

Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Maddox JF, Ganey PE, Roth RA. Luyendyk JP, et al. Toxicol Sci. 2006 Apr;90(2):569-85. doi: 10.1093/toxsci/kfj103. Epub 2006 Jan 16. Toxicol Sci. 2006. PMID: 16415329

3

p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine.

Deng X, Lu J, Lehman-McKeeman LD, Malle E, Crandall DL, Ganey PE, Roth RA. Deng X, et al. J Pharmacol Exp Ther. 2008 Jul;326(1):144-52. doi: 10.1124/jpet.108.137497. Epub 2008 Apr 4. J Pharmacol Exp Ther. 2008. PMID: 18390808 Free PMC article.

4

Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example.

Liguori MJ, Ditewig AC, Maddox JF, Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Waring JF, Ganey PE, Roth RA, Blomme EA. Liguori MJ, et al. Int J Mol Sci. 2010 Nov 18;11(11):4697-714. doi: 10.3390/ijms11114697. Int J Mol Sci. 2010. PMID: 21151465 Free PMC article.

5

p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.

Nelson DM, Bhaskaran V, Foster WR, Lehman-McKeeman LD. Nelson DM, et al. Toxicol Sci. 2006 Dec;94(2):272-80. doi: 10.1093/toxsci/kfl115. Epub 2006 Sep 25. Toxicol Sci. 2006. PMID: 17000718

6

Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats.

Wong H, Lehman-McKeeman LD, Grubb MF, Grossman SJ, Bhaskaran VM, Solon EG, Shen HS, Gerson RJ, Car BD, Zhao B, Gemzik B. Wong H, et al. Toxicol Sci. 2005 Apr;84(2):232-42. doi: 10.1093/toxsci/kfi094. Epub 2005 Jan 26. Toxicol Sci. 2005. PMID: 15673846

7

A retrospective analysis of toxicogenomics in the safety assessment of drug candidates.

Foster WR, Chen SJ, He A, Truong A, Bhaskaran V, Nelson DM, Dambach DM, Lehman-McKeeman LD, Car BD. Foster WR, et al. Toxicol Pathol. 2007 Aug;35(5):621-35. doi: 10.1080/01926230701419063. Toxicol Pathol. 2007. PMID: 17654404 Review.

8

Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1).

Otieno MA, Bhaskaran V, Janovitz E, Callejas Y, Foster WB, Washburn W, Megill JR, Lehman-McKeeman L, Gemzik B. Otieno MA, et al. Toxicol Sci. 2017 Feb;155(2):379-388. doi: 10.1093/toxsci/kfw216. Epub 2016 Oct 20. Toxicol Sci. 2017. PMID: 28025230

9

Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2.

Fisher CD, Augustine LM, Maher JM, Nelson DM, Slitt AL, Klaassen CD, Lehman-McKeeman LD, Cherrington NJ. Fisher CD, et al. Drug Metab Dispos. 2007 Jun;35(6):995-1000. doi: 10.1124/dmd.106.014340. Epub 2007 Mar 12. Drug Metab Dispos. 2007. PMID: 17353348

10

Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.

Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reily MD, Robertson D, Stevens GJ, Luke P, Breau AP, Cantor GH, Bible RH, Niederhauser U, Senn H, Schlotterbeck G, Sidelmann UG, Laursen SM, Tymiak A, Car BD, Lehman-McKeeman L, Colet JM, Loukaci A, Thomas C. Lindon JC, et al. Toxicol Appl Pharmacol. 2003 Mar 15;187(3):137-46. doi: 10.1016/s0041-008x(02)00079-0. Toxicol Appl Pharmacol. 2003. PMID: 12662897

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