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Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.
Kim P, Zhang YM, Shenoy G, Nguyen QA, Boshoff HI, Manjunatha UH, Goodwin MB, Lonsdale J, Price AC, Miller DJ, Duncan K, White SW, Rock CO, Barry CE 3rd, Dowd CS. Kim P, et al. Among authors: rock co. J Med Chem. 2006 Jan 12;49(1):159-71. doi: 10.1021/jm050825p. J Med Chem. 2006. PMID: 16392800 Free PMC article.
Lipid biosynthesis as a target for antibacterial agents.
Heath RJ, White SW, Rock CO. Heath RJ, et al. Among authors: rock co. Prog Lipid Res. 2001 Nov;40(6):467-97. doi: 10.1016/s0163-7827(01)00012-1. Prog Lipid Res. 2001. PMID: 11591436 Review.
269 results