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A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4.
Asensio JL, Hidalgo A, Bastida A, Torrado M, Corzana F, Chiara JL, García-Junceda E, Cañada J, Jiménez-Barbero J. Asensio JL, et al. Among authors: hidalgo a. J Am Chem Soc. 2005 Jun 15;127(23):8278-9. doi: 10.1021/ja051722z. J Am Chem Soc. 2005. PMID: 15941249 Free article.
Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase.
Corzana F, Cuesta I, Bastida A, Hidalgo A, Latorre M, González C, García-Junceda E, Jiménez-Barbero J, Asensio JL. Corzana F, et al. Among authors: hidalgo a. Chemistry. 2005 Aug 19;11(17):5102-13. doi: 10.1002/chem.200400941. Chemistry. 2005. PMID: 15984036
Experimental evidence for the existence of non-exo-anomeric conformations in branched oligosaccharides: NMR analysis of the structure and dynamics of aminoglycosides of the neomycin family.
Asensio JL, Hidalgo A, Cuesta I, González C, Cañada J, Vicent C, Chiara JL, Cuevas G, Jiménez-Barbero J. Asensio JL, et al. Among authors: hidalgo a. Chemistry. 2002 Nov 15;8(22):5228-40. doi: 10.1002/1521-3765(20021115)8:22<5228::AID-CHEM5228>3.0.CO;2-L. Chemistry. 2002. PMID: 12613042
Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes.
González-Rubio S, Hidalgo AB, Ferrín G, Bello RI, González R, Gahete MD, Ranchal I, Rodríguez BA, Barrera P, Aguilar-Melero P, Linares CI, Castaño JP, Victor VM, De la Mata M, Muntané J. González-Rubio S, et al. Among authors: hidalgo ab. Chem Res Toxicol. 2009 Dec;22(12):1984-91. doi: 10.1021/tx900327t. Chem Res Toxicol. 2009. PMID: 20020783
N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes.
González R, Ferrín G, Hidalgo AB, Ranchal I, López-Cillero P, Santos-Gónzalez M, López-Lluch G, Briceño J, Gómez MA, Poyato A, Villalba JM, Navas P, de la Mata M, Muntané J. González R, et al. Among authors: hidalgo ab. Chem Biol Interact. 2009 Sep 14;181(1):95-106. doi: 10.1016/j.cbi.2009.06.003. Epub 2009 Jun 11. Chem Biol Interact. 2009. PMID: 19523936
Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes.
González-Rubio S, Linares CI, Bello RI, González R, Ferrín G, Hidalgo AB, Muñoz-Gomariz E, Rodríguez BA, Barrera P, Ranchal I, Durán-Prado M, Aguilar-Melero P, De la Mata M, Muntané J. González-Rubio S, et al. Among authors: hidalgo ab. Toxicol Appl Pharmacol. 2010 Jan 15;242(2):165-72. doi: 10.1016/j.taap.2009.10.003. Epub 2009 Oct 23. Toxicol Appl Pharmacol. 2010. PMID: 19837105
891 results