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Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.
Eur J Med Chem. 2016 Nov 29;124:852-880. doi: 10.1016/j.ejmech.2016.09.012. Epub 2016 Sep 7.
Eur J Med Chem. 2016.
PMID: 27654218
Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids.
Steffan T, Renukappa-Gutke T, Höfner G, Wanner KT.
Steffan T, et al. Among authors: renukappa gutke t.
Bioorg Med Chem. 2015 Mar 15;23(6):1284-306. doi: 10.1016/j.bmc.2015.01.035. Epub 2015 Feb 3.
Bioorg Med Chem. 2015.
PMID: 25698617
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Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists.
Müller A, Höfner G, Renukappa-Gutke T, Parsons CG, Wanner KT.
Müller A, et al. Among authors: renukappa gutke t.
Bioorg Med Chem Lett. 2011 Oct 1;21(19):5795-9. doi: 10.1016/j.bmcl.2011.07.119. Epub 2011 Aug 6.
Bioorg Med Chem Lett. 2011.
PMID: 21875803
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AWD-12-281 (inhaled) (elbion/GlaxoSmithKline).
Gutke HJ, Guse JH, Khobzaoui M, Renukappa-Gutke T, Burnet M.
Gutke HJ, et al. Among authors: renukappa gutke t.
Curr Opin Investig Drugs. 2005 Nov;6(11):1149-58.
Curr Opin Investig Drugs. 2005.
PMID: 16312137
Review.
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