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Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes.
Rao AU, Shao N, Aslanian RG, Chan TY, Degrado SJ, Wang L, McKittrick B, Senior M, West RE Jr, Williams SM, Wu RL, Hwa J, Patel B, Zheng S, Sondey C, Palani A. Rao AU, et al. Among authors: west re jr. ACS Med Chem Lett. 2011 Nov 21;3(3):198-202. doi: 10.1021/ml200250t. eCollection 2012 Mar 8. ACS Med Chem Lett. 2011. PMID: 24900450 Free PMC article.
Discovery of a series of potent arylthiadiazole H(3) antagonists.
Xiao D, Palani A, Sofolarides M, Huang Y, Aslanian R, Vaccaro H, Hong L, McKittrick B, West RE Jr, Williams SM, Wu RL, Hwa J, Sondey C, Lachowicz J. Xiao D, et al. Among authors: west re jr. Bioorg Med Chem Lett. 2011 Jan 15;21(2):861-4. doi: 10.1016/j.bmcl.2010.11.065. Epub 2010 Nov 21. Bioorg Med Chem Lett. 2011. PMID: 21186123
Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists.
Berlin M, Ting PC, Vaccaro WD, Aslanian R, McCormick KD, Lee JF, Albanese MM, Mutahi MW, Piwinski JJ, Shih NY, Duguma L, Solomon DM, Zhou W, Sher R, Favreau L, Bryant M, Korfmacher WA, Nardo C, West RE Jr, Anthes JC, Williams SM, Wu RL, Susan She H, Rivelli MA, Corboz MR, Hey JA. Berlin M, et al. Among authors: west re jr. Bioorg Med Chem Lett. 2006 Feb 15;16(4):989-94. doi: 10.1016/j.bmcl.2005.10.087. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16297617
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold.
Vaccaro WD, Sher R, Berlin M, Shih NY, Aslanian R, Schwerdt JH, McCormick KD, Piwinski JJ, West RE Jr, Anthes JC, Williams SM, Wu RL, She HS, Rivelli MA, Mutter JC, Corboz MR, Hey JA, Favreau L. Vaccaro WD, et al. Among authors: west re jr. Bioorg Med Chem Lett. 2006 Jan 15;16(2):395-9. doi: 10.1016/j.bmcl.2005.09.076. Epub 2005 Oct 21. Bioorg Med Chem Lett. 2006. PMID: 16246552
33 results