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Benzotriazole-assisted thioacylation.
J Org Chem. 2005 Sep 30;70(20):7866-81. doi: 10.1021/jo050670t.
J Org Chem. 2005.
PMID: 16277306
Alpha-nitro ketone synthesis using N-acylbenzotriazoles.
Katritzky AR, Abdel-Fattah AA, Gromova AV, Witek R, Steel PJ.
Katritzky AR, et al.
J Org Chem. 2005 Nov 11;70(23):9211-4. doi: 10.1021/jo051231x.
J Org Chem. 2005.
PMID: 16268592
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1-(Alkyl/arylthiocarbamoyl)benzotriazoles as stable isothiocyanate equivalents: synthesis of Di- and trisubstituted thioureas.
Katritzky AR, Ledoux S, Witek RM, Nair SK.
Katritzky AR, et al. Among authors: witek rm.
J Org Chem. 2004 Apr 30;69(9):2976-82. doi: 10.1021/jo035680d.
J Org Chem. 2004.
PMID: 15104434
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The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies.
Joseph CG, Wilson KR, Wood MS, Sorenson NB, Phan DV, Xiang Z, Witek RM, Haskell-Luevano C.
Joseph CG, et al. Among authors: witek rm.
J Med Chem. 2008 Mar 13;51(5):1423-31. doi: 10.1021/jm701303z. Epub 2008 Feb 14.
J Med Chem. 2008.
PMID: 18271518
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Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR.
Singh A, Wilczynski A, Holder JR, Witek RM, Dirain ML, Xiang Z, Edison AS, Haskell-Luevano C.
Singh A, et al. Among authors: witek rm.
J Med Chem. 2011 Mar 10;54(5):1379-90. doi: 10.1021/jm101425m. Epub 2011 Feb 9.
J Med Chem. 2011.
PMID: 21306168
Free PMC article.
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Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R).
Singh A, Dirain M, Witek R, Rocca JR, Edison AS, Haskell-Luevano C.
Singh A, et al.
J Med Chem. 2013 Apr 11;56(7):2747-63. doi: 10.1021/jm301253y. Epub 2013 Mar 25.
J Med Chem. 2013.
PMID: 23432160
Free PMC article.
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