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Page 1
Antiparasitic compounds that target DNA.
Wilson WD, Tanious FA, Mathis A, Tevis D, Hall JE, Boykin DW. Wilson WD, et al. Among authors: mathis a. Biochimie. 2008 Jul;90(7):999-1014. doi: 10.1016/j.biochi.2008.02.017. Epub 2008 Mar 4. Biochimie. 2008. PMID: 18343228 Free PMC article. Review.
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
Mathis AM, Bridges AS, Ismail MA, Kumar A, Francesconi I, Anbazhagan M, Hu Q, Tanious FA, Wenzler T, Saulter J, Wilson WD, Brun R, Boykin DW, Tidwell RR, Hall JE. Mathis AM, et al. Antimicrob Agents Chemother. 2007 Aug;51(8):2801-10. doi: 10.1128/AAC.00005-07. Epub 2007 May 21. Antimicrob Agents Chemother. 2007. PMID: 17517831 Free PMC article.
Preclinical Characterization and In Vivo Efficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein.
Pouliot JJ, Thomson M, Xie M, Horton J, Johnson J, Krull D, Mathis A, Morikawa Y, Parks D, Peterson R, Shimada T, Thomas E, Vamathevan J, Van Horn S, Xiong Z, Hamatake R, Peat AJ. Pouliot JJ, et al. Among authors: mathis a. Antimicrob Agents Chemother. 2015 Oct;59(10):6539-50. doi: 10.1128/AAC.00813-15. Epub 2015 Aug 10. Antimicrob Agents Chemother. 2015. PMID: 26259798 Free PMC article.
Hepatitis C replication inhibitors that target the viral NS4B protein.
Miller JF, Chong PY, Shotwell JB, Catalano JG, Tai VW, Fang J, Banka AL, Roberts CD, Youngman M, Zhang H, Xiong Z, Mathis A, Pouliot JJ, Hamatake RK, Price DJ, Seal JW 3rd, Stroup LL, Creech KL, Carballo LH, Todd D, Spaltenstein A, Furst S, Hong Z, Peat AJ. Miller JF, et al. Among authors: mathis a. J Med Chem. 2014 Mar 13;57(5):2107-20. doi: 10.1021/jm400125h. Epub 2013 Apr 19. J Med Chem. 2014. PMID: 23544424
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.
Chong PY, Shotwell JB, Miller J, Price DJ, Maynard A, Voitenleitner C, Mathis A, Williams S, Pouliot JJ, Creech K, Wang F, Fang J, Zhang H, Tai VW, Turner E, Kahler KM, Crosby R, Peat AJ. Chong PY, et al. Among authors: mathis a. J Med Chem. 2019 Apr 11;62(7):3254-3267. doi: 10.1021/acs.jmedchem.8b01719. Epub 2019 Mar 7. J Med Chem. 2019. PMID: 30763090 Free PMC article.
A randomized, double blind, dose escalation, first time in human study to assess the safety, tolerability, pharmacokinetics, and antiviral activity of single doses of GSK2485852 in chronically infected hepatitis C subjects.
Wilfret DA, Walker J, Voitenleitner C, Baptiste-Brown S, Lovern M, Kim J, Adkison K, Shotwell B, Mathis A, Moss L, Lee D, Yu L, Gan J, Spaltenstein A. Wilfret DA, et al. Among authors: mathis a. Clin Pharmacol Drug Dev. 2014 Nov;3(6):439-48. doi: 10.1002/cpdd.142. Epub 2014 Oct 20. Clin Pharmacol Drug Dev. 2014. PMID: 27129119 Clinical Trial.
472 results