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Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.
Chung S, Timmins JM, Duong M, Degirolamo C, Rong S, Sawyer JK, Singaraja RR, Hayden MR, Maeda N, Rudel LL, Shelness GS, Parks JS. Chung S, et al. Among authors: timmins jm. J Biol Chem. 2010 Apr 16;285(16):12197-209. doi: 10.1074/jbc.M109.096933. Epub 2010 Feb 23. J Biol Chem. 2010. PMID: 20178985 Free PMC article.
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo.
Brunham LR, Kruit JK, Iqbal J, Fievet C, Timmins JM, Pape TD, Coburn BA, Bissada N, Staels B, Groen AK, Hussain MM, Parks JS, Kuipers F, Hayden MR. Brunham LR, et al. Among authors: timmins jm. J Clin Invest. 2006 Apr;116(4):1052-62. doi: 10.1172/JCI27352. Epub 2006 Mar 16. J Clin Invest. 2006. PMID: 16543947 Free PMC article.
Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.
Brunham LR, Singaraja RR, Duong M, Timmins JM, Fievet C, Bissada N, Kang MH, Samra A, Fruchart JC, McManus B, Staels B, Parks JS, Hayden MR. Brunham LR, et al. Among authors: timmins jm. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):548-54. doi: 10.1161/ATVBAHA.108.182303. Epub 2009 Feb 5. Arterioscler Thromb Vasc Biol. 2009. PMID: 19201688
Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice.
Singaraja RR, Stahmer B, Brundert M, Merkel M, Heeren J, Bissada N, Kang M, Timmins JM, Ramakrishnan R, Parks JS, Hayden MR, Rinninger F. Singaraja RR, et al. Among authors: timmins jm. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1821-7. doi: 10.1161/01.ATV.0000229219.13757.a2. Epub 2006 May 25. Arterioscler Thromb Vasc Biol. 2006. PMID: 16728652
Macrophage apoptosis in advanced atherosclerosis.
Tabas I, Seimon T, Timmins J, Li G, Lim W. Tabas I, et al. Ann N Y Acad Sci. 2009 Sep;1173 Suppl 1(Suppl 1):E40-5. doi: 10.1111/j.1749-6632.2009.04957.x. Ann N Y Acad Sci. 2009. PMID: 19751413 Free PMC article.
11 results