Rush TS 3rd - Search Results

1

Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.

Moschos SJ, Sullivan RJ, Hwu WJ, Ramanathan RK, Adjei AA, Fong PC, Shapira-Frommer R, Tawbi HA, Rubino J, Rush TS 3rd, Zhang D, Miselis NR, Samatar AA, Chun P, Rubin EH, Schiller J, Long BJ, Dayananth P, Carr D, Kirschmeier P, Bishop WR, Deng Y, Cooper A, Shipps GW, Moreno BH, Robert L, Ribas A, Flaherty KT. Moschos SJ, et al. Among authors: rush ts 3rd. JCI Insight. 2018 Feb 22;3(4):e92352. doi: 10.1172/jci.insight.92352. eCollection 2018 Feb 22. JCI Insight. 2018. PMID: 29467321 Free PMC article. Clinical Trial.

2

Efficient identification of novel leads by dynamic focused screening: PDK1 case stud.

Sun D, Jung J, Rush TS 3rd, Xu Z, Weber MJ, Bobkova E, Northrup A, Kariv I. Sun D, et al. Among authors: rush ts 3rd. Comb Chem High Throughput Screen. 2010 Jan;13(1):16-26. doi: 10.2174/138620710790218186. Comb Chem High Throughput Screen. 2010. PMID: 20214573

3

3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.

Li W, Hu Y, Li J, Thomason JR, DeVincentis D, Du X, Wu J, Hotchandani R, Rush TS 3rd, Skotnicki JS, Tam S, Chockalingam PS, Morris EA, Levin JI. Li W, et al. Among authors: rush ts 3rd. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4546-50. doi: 10.1016/j.bmcl.2009.07.008. Epub 2009 Jul 9. Bioorg Med Chem Lett. 2009. PMID: 19625186

4

Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor.

Janovick JA, Patny A, Mosley R, Goulet MT, Altman MD, Rush TS 3rd, Cornea A, Conn PM. Janovick JA, et al. Among authors: rush ts 3rd. Mol Endocrinol. 2009 Feb;23(2):157-68. doi: 10.1210/me.2008-0384. Epub 2008 Dec 18. Mol Endocrinol. 2009. PMID: 19095769 Free PMC article.

5

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.

Tsao DH, Sutherland AG, Jennings LD, Li Y, Rush TS 3rd, Alvarez JC, Ding W, Dushin EG, Dushin RG, Haney SA, Kenny CH, Malakian AK, Nilakantan R, Mosyak L. Tsao DH, et al. Among authors: rush ts 3rd. Bioorg Med Chem. 2006 Dec 1;14(23):7953-61. doi: 10.1016/j.bmc.2006.07.050. Epub 2006 Aug 17. Bioorg Med Chem. 2006. PMID: 16919463

6

Functional, biophysical, and structural bases for antibacterial activity of tigecycline.

Olson MW, Ruzin A, Feyfant E, Rush TS 3rd, O'Connell J, Bradford PA. Olson MW, et al. Among authors: rush ts 3rd. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. doi: 10.1128/AAC.01499-05. Antimicrob Agents Chemother. 2006. PMID: 16723578 Free PMC article.

7

Structure-based identification of the binding site for the hemiasterlin analogue HTI-286 on tubulin.

Ravi M, Zask A, Rush TS 3rd. Ravi M, et al. Among authors: rush ts 3rd. Biochemistry. 2005 Dec 6;44(48):15871-9. doi: 10.1021/bi051268b. Biochemistry. 2005. PMID: 16313189

8

Synthesis and SAR of highly selective MMP-13 inhibitors.

Li J, Rush TS 3rd, Li W, DeVincentis D, Du X, Hu Y, Thomason JR, Xiang JS, Skotnicki JS, Tam S, Cunningham KM, Chockalingam PS, Morris EA, Levin JI. Li J, et al. Among authors: rush ts 3rd. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4961-6. doi: 10.1016/j.bmcl.2005.08.001. Bioorg Med Chem Lett. 2005. PMID: 16153831

9

Identification of potent and selective MMP-13 inhibitors.

Wu J, Rush TS 3rd, Hotchandani R, Du X, Geck M, Collins E, Xu ZB, Skotnicki J, Levin JI, Lovering FE. Wu J, et al. Among authors: rush ts 3rd. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4105-9. doi: 10.1016/j.bmcl.2005.06.019. Bioorg Med Chem Lett. 2005. PMID: 16005220

10

A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction.

Rush TS 3rd, Grant JA, Mosyak L, Nicholls A. Rush TS 3rd, et al. J Med Chem. 2005 Mar 10;48(5):1489-95. doi: 10.1021/jm040163o. J Med Chem. 2005. PMID: 15743191

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