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Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
Shi GQ, Dropinski JF, McKeever BM, Xu S, Becker JW, Berger JP, MacNaul KL, Elbrecht A, Zhou G, Doebber TW, Wang P, Chao YS, Forrest M, Heck JV, Moller DE, Jones AB. Shi GQ, et al. Among authors: chao ys. J Med Chem. 2005 Jun 30;48(13):4457-68. doi: 10.1021/jm0502135. J Med Chem. 2005. PMID: 15974597
A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis.
Guo Q, Sahoo SP, Wang PR, Milot DP, Ippolito MC, Wu MS, Baffic J, Biswas C, Hernandez M, Lam MH, Sharma N, Han W, Kelly LJ, MacNaul KL, Zhou G, Desai R, Heck JV, Doebber TW, Berger JP, Moller DE, Sparrow CP, Chao YS, Wright SD. Guo Q, et al. Among authors: chao ys. Endocrinology. 2004 Apr;145(4):1640-8. doi: 10.1210/en.2003-1270. Epub 2003 Dec 30. Endocrinology. 2004. PMID: 14701675
(2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents.
Koyama H, Miller DJ, Boueres JK, Desai RC, Jones AB, Berger JP, MacNaul KL, Kelly LJ, Doebber TW, Wu MS, Zhou G, Wang PR, Ippolito MC, Chao YS, Agrawal AK, Franklin R, Heck JV, Wright SD, Moller DE, Sahoo SP. Koyama H, et al. Among authors: chao ys. J Med Chem. 2004 Jun 3;47(12):3255-63. doi: 10.1021/jm030621d. J Med Chem. 2004. PMID: 15163205
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.
Singh SB, Ondeyka JG, Liu W, Chen S, Chen TS, Li X, Bouffard A, Dropinski J, Jones AB, McCormick S, Hayes N, Wang J, Sharma N, Macnaul K, Hernandez M, Chao YS, Baffic J, Lam MH, Burton C, Sparrow CP, Menke JG. Singh SB, et al. Among authors: chao ys. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2824-8. doi: 10.1016/j.bmcl.2005.03.100. Bioorg Med Chem Lett. 2005. PMID: 15911262
PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.
Hermanowski-Vosatka A, Gerhold D, Mundt SS, Loving VA, Lu M, Chen Y, Elbrecht A, Wu M, Doebber T, Kelly L, Milot D, Guo Q, Wang PR, Ippolito M, Chao YS, Wright SD, Thieringer R. Hermanowski-Vosatka A, et al. Among authors: chao ys. Biochem Biophys Res Commun. 2000 Dec 20;279(2):330-6. doi: 10.1006/bbrc.2000.3966. Biochem Biophys Res Commun. 2000. PMID: 11118287
233 results