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MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo-allergic and anaphylactoid reactions.
Grimes J, Desai S, Charter NW, Lodge J, Moita Santos R, Isidro-Llobet A, Mason AM, Wu Z, Wolfe LA 3rd, Anantharaman L, Green A, Bridges AM, Dalmas Wilk DA, Brown AJ. Grimes J, et al. Among authors: wolfe la 3rd. Pharmacol Res Perspect. 2019 Dec 2;7(6):e00547. doi: 10.1002/prp2.547. eCollection 2019 Dec. Pharmacol Res Perspect. 2019. PMID: 31832205 Free PMC article.