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A phase I clinical trial of a ribozyme-based angiogenesis inhibitor targeting vascular endothelial growth factor receptor-1 for patients with refractory solid tumors.
Weng DE, Masci PA, Radka SF, Jackson TE, Weiss PA, Ganapathi R, Elson PJ, Capra WB, Parker VP, Lockridge JA, Cowens JW, Usman N, Borden EC. Weng DE, et al. Among authors: usman n. Mol Cancer Ther. 2005 Jun;4(6):948-55. doi: 10.1158/1535-7163.MCT-04-0210. Mol Cancer Ther. 2005. PMID: 15956252 Clinical Trial.
Angiozyme: a novel angiogenesis inhibitor.
Weng DE, Usman N. Weng DE, et al. Among authors: usman n. Curr Oncol Rep. 2001 Mar;3(2):141-6. doi: 10.1007/s11912-001-0014-7. Curr Oncol Rep. 2001. PMID: 11177746 Review.
Safety and pharmacokinetic study of RPI.4610 (ANGIOZYME), an anti-VEGFR-1 ribozyme, in combination with carboplatin and paclitaxel in patients with advanced solid tumors.
Kobayashi H, Eckhardt SG, Lockridge JA, Rothenberg ML, Sandler AB, O'Bryant CL, Cooper W, Holden SN, Aitchison RD, Usman N, Wolin M, Basche ML. Kobayashi H, et al. Among authors: usman n. Cancer Chemother Pharmacol. 2005 Oct;56(4):329-36. doi: 10.1007/s00280-004-0968-x. Epub 2005 May 20. Cancer Chemother Pharmacol. 2005. PMID: 15906031 Clinical Trial.
Synthesis, deprotection, analysis and purification of RNA and ribozymes.
Wincott F, DiRenzo A, Shaffer C, Grimm S, Tracz D, Workman C, Sweedler D, Gonzalez C, Scaringe S, Usman N. Wincott F, et al. Among authors: usman n. Nucleic Acids Res. 1995 Jul 25;23(14):2677-84. doi: 10.1093/nar/23.14.2677. Nucleic Acids Res. 1995. PMID: 7544462 Free PMC article.
Hammerhead ribozyme engineering.
Usman N, Beigelman L, McSwiggen JA. Usman N, et al. Curr Opin Struct Biol. 1996 Aug;6(4):527-33. doi: 10.1016/s0959-440x(96)80119-9. Curr Opin Struct Biol. 1996. PMID: 8794164 Review.
180 results