Mintzer RJ - Search Results

1

A novel high-throughput screening format to identify inhibitors of secreted acid sphingomyelinase.

Mintzer RJ, Appell KC, Cole A, Johns A, Pagila R, Polokoff MA, Tabas I, Snider RM, Meurer-Ogden JA. Mintzer RJ, et al. J Biomol Screen. 2005 Apr;10(3):225-34. doi: 10.1177/1087057104272546. J Biomol Screen. 2005. PMID: 15809318

2

A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase.

Seto M, Whitlow M, McCarrick MA, Srinivasan S, Zhu Y, Pagila R, Mintzer R, Light D, Johns A, Meurer-Ogden JA. Seto M, et al. Protein Sci. 2004 Dec;13(12):3172-86. doi: 10.1110/ps.04966204. Protein Sci. 2004. PMID: 15557261 Free PMC article.

3

Differential effects of IFN-beta1b on the proliferation of human vascular smooth muscle and endothelial cells.

Mintzer RJ, Croze E, Rubanyi GM, Johns A. Mintzer RJ, et al. J Interferon Cytokine Res. 1998 Nov;18(11):939-45. doi: 10.1089/jir.1998.18.939. J Interferon Cytokine Res. 1998. PMID: 9858315

4

Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling.

Marathe S, Schissel SL, Yellin MJ, Beatini N, Mintzer R, Williams KJ, Tabas I. Marathe S, et al. J Biol Chem. 1998 Feb 13;273(7):4081-8. doi: 10.1074/jbc.273.7.4081. J Biol Chem. 1998. PMID: 9461601 Free article.

5

Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates.

Liu Y, Beresini MH, Johnson A, Mintzer R, Shah K, Clark K, Schmidt S, Lewis C, Liimatta M, Elliott LO, Gustafson A, Heise CE. Liu Y, et al. J Biomol Screen. 2012 Feb;17(2):225-36. doi: 10.1177/1087057111421525. Epub 2011 Sep 22. J Biomol Screen. 2012. PMID: 21940710

6

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C.

Mintzer R, Ramaswamy S, Shah K, Hannoush RN, Pozniak CD, Cohen F, Zhao X, Plise E, Lewcock JW, Heise CE. Mintzer R, et al. PLoS One. 2012;7(1):e30376. doi: 10.1371/journal.pone.0030376. Epub 2012 Jan 12. PLoS One. 2012. PMID: 22253931 Free PMC article.

7

Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.

Lee W, Crawford JJ, Aliagas I, Murray LJ, Tay S, Wang W, Heise CE, Hoeflich KP, La H, Mathieu S, Mintzer R, Ramaswamy S, Rouge L, Rudolph J. Lee W, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3518-24. doi: 10.1016/j.bmcl.2016.06.031. Epub 2016 Jun 15. Bioorg Med Chem Lett. 2016. PMID: 27346791

8

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase.

Morisaki JH, Smith PA, Date SV, Kajihara KK, Truong CL, Modrusan Z, Yan D, Kang J, Xu M, Shah IM, Mintzer R, Kofoed EM, Cheung TK, Arnott D, Koehler MF, Heise CE, Brown EJ, Tan MW, Hazenbos WL. Morisaki JH, et al. mBio. 2016 Sep 6;7(5):e00412-16. doi: 10.1128/mBio.00412-16. mBio. 2016. PMID: 27601569 Free PMC article.

9

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.

Staben ST, Feng JA, Lyle K, Belvin M, Boggs J, Burch JD, Chua CC, Cui H, DiPasquale AG, Friedman LS, Heise C, Koeppen H, Kotey A, Mintzer R, Oh A, Roberts DA, Rouge L, Rudolph J, Tam C, Wang W, Xiao Y, Young A, Zhang Y, Hoeflich KP. Staben ST, et al. J Med Chem. 2014 Feb 13;57(3):1033-45. doi: 10.1021/jm401768t. Epub 2014 Feb 4. J Med Chem. 2014. PMID: 24432870

10

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

Crawford JJ, Lee W, Aliagas I, Mathieu S, Hoeflich KP, Zhou W, Wang W, Rouge L, Murray L, La H, Liu N, Fan PW, Cheong J, Heise CE, Ramaswamy S, Mintzer R, Liu Y, Chao Q, Rudolph J. Crawford JJ, et al. J Med Chem. 2015 Jun 25;58(12):5121-36. doi: 10.1021/acs.jmedchem.5b00572. Epub 2015 Jun 12. J Med Chem. 2015. PMID: 26030457

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