Wells TN - Search Results

1

The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors.

Shaw JP, Johnson Z, Borlat F, Zwahlen C, Kungl A, Roulin K, Harrenga A, Wells TN, Proudfoot AE. Shaw JP, et al. Among authors: wells tn. Structure. 2004 Nov;12(11):2081-93. doi: 10.1016/j.str.2004.08.014. Structure. 2004. PMID: 15530372 Free article.

2

Strategies for chemokine antagonists as therapeutics.

Proudfoot AE, Power CA, Rommel C, Wells TN. Proudfoot AE, et al. Among authors: wells tn. Semin Immunol. 2003 Feb;15(1):57-65. doi: 10.1016/s1044-5323(02)00128-8. Semin Immunol. 2003. PMID: 12495641 Review.

3

Multi-faceted strategies to combat disease by interference with the chemokine system.

Johnson Z, Schwarz M, Power CA, Wells TN, Proudfoot AE. Johnson Z, et al. Among authors: wells tn. Trends Immunol. 2005 May;26(5):268-74. doi: 10.1016/j.it.2005.03.001. Trends Immunol. 2005. PMID: 15866240 Review.

4

The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity.

Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN. Proudfoot AE, et al. Among authors: wells tn. J Biol Chem. 2001 Apr 6;276(14):10620-6. doi: 10.1074/jbc.M010867200. Epub 2000 Dec 14. J Biol Chem. 2001. PMID: 11116158 Free article.

5

Chemokine inhibition--why, when, where, which and how?

Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C. Johnson Z, et al. Among authors: wells tn. Biochem Soc Trans. 2004 Apr;32(Pt 2):366-77. doi: 10.1042/bst0320366. Biochem Soc Trans. 2004. PMID: 15046611 Review.

6

Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines.

Proudfoot AE, Handel TM, Johnson Z, Lau EK, LiWang P, Clark-Lewis I, Borlat F, Wells TN, Kosco-Vilbois MH. Proudfoot AE, et al. Among authors: wells tn. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1885-90. doi: 10.1073/pnas.0334864100. Epub 2003 Feb 5. Proc Natl Acad Sci U S A. 2003. PMID: 12571364 Free PMC article.

7

Inhibition of airway inflammation by amino-terminally modified RANTES/CC chemokine ligand 5 analogues is not mediated through CCR3.

Chvatchko Y, Proudfoot AE, Buser R, Juillard P, Alouani S, Kosco-Vilbois M, Coyle AJ, Nibbs RJ, Graham G, Offord RE, Wells TN. Chvatchko Y, et al. Among authors: wells tn. J Immunol. 2003 Nov 15;171(10):5498-506. doi: 10.4049/jimmunol.171.10.5498. J Immunol. 2003. PMID: 14607956

8

Interference with heparin binding and oligomerization creates a novel anti-inflammatory strategy targeting the chemokine system.

Johnson Z, Kosco-Vilbois MH, Herren S, Cirillo R, Muzio V, Zaratin P, Carbonatto M, Mack M, Smailbegovic A, Rose M, Lever R, Page C, Wells TN, Proudfoot AE. Johnson Z, et al. Among authors: wells tn. J Immunol. 2004 Nov 1;173(9):5776-85. doi: 10.4049/jimmunol.173.9.5776. J Immunol. 2004. PMID: 15494530

9

Chemokine blockers--therapeutics in the making?

Wells TN, Power CA, Shaw JP, Proudfoot AE. Wells TN, et al. Trends Pharmacol Sci. 2006 Jan;27(1):41-7. doi: 10.1016/j.tips.2005.11.001. Epub 2005 Nov 28. Trends Pharmacol Sci. 2006. PMID: 16310864 Review.

10

An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo.

Handel TM, Johnson Z, Rodrigues DH, Dos Santos AC, Cirillo R, Muzio V, Riva S, Mack M, Déruaz M, Borlat F, Vitte PA, Wells TN, Teixeira MM, Proudfoot AE. Handel TM, et al. Among authors: wells tn. J Leukoc Biol. 2008 Oct;84(4):1101-8. doi: 10.1189/jlb.0108061. Epub 2008 Jul 28. J Leukoc Biol. 2008. PMID: 18662971 Free PMC article.

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