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Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.
Buss H, Dörrie A, Schmitz ML, Hoffmann E, Resch K, Kracht M. Buss H, et al. Among authors: dorrie a. J Biol Chem. 2004 Dec 31;279(53):55633-43. doi: 10.1074/jbc.M409825200. Epub 2004 Oct 15. J Biol Chem. 2004. PMID: 15489227 Free article.
Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes.
Holzberg D, Knight CG, Dittrich-Breiholz O, Schneider H, Dörrie A, Hoffmann E, Resch K, Kracht M. Holzberg D, et al. Among authors: dorrie a. J Biol Chem. 2003 Oct 10;278(41):40213-23. doi: 10.1074/jbc.M304058200. Epub 2003 Jun 27. J Biol Chem. 2003. PMID: 12832416 Free article.
Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.
Thiefes A, Wolter S, Mushinski JF, Hoffmann E, Dittrich-Breiholz O, Graue N, Dörrie A, Schneider H, Wirth D, Luckow B, Resch K, Kracht M. Thiefes A, et al. Among authors: dorrie a. J Biol Chem. 2005 Jul 29;280(30):27728-41. doi: 10.1074/jbc.M411657200. Epub 2005 Apr 18. J Biol Chem. 2005. PMID: 15837794 Free article.
The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation.
Holtmann H, Enninga J, Kalble S, Thiefes A, Dorrie A, Broemer M, Winzen R, Wilhelm A, Ninomiya-Tsuji J, Matsumoto K, Resch K, Kracht M. Holtmann H, et al. Among authors: dorrie a. J Biol Chem. 2001 Feb 2;276(5):3508-16. doi: 10.1074/jbc.M004376200. Epub 2000 Oct 24. J Biol Chem. 2001. PMID: 11050078 Free article.
Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1.
Schwarzer A, Oliveira M, Kleppa MJ, Slattery SD, Anantha A, Cooper A, Hannink M, Schambach A, Dörrie A, Kotlyarov A, Gaestel M, Hembrough T, Levine J, Luther M, Stocum M, Stiles L, Weinstock DM, Liesa M, Kostura MJ. Schwarzer A, et al. Among authors: dorrie a. Mol Cancer Ther. 2023 Nov 1;22(11):1290-1303. doi: 10.1158/1535-7163.MCT-22-0718. Mol Cancer Ther. 2023. PMID: 37643767 Free PMC article.
On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer.
Boudghene-Stambouli F, Soulez M, Ronkina N, Dörrie A, Kotlyarov A, Seternes OM, Gaestel M, Meloche S. Boudghene-Stambouli F, et al. Among authors: dorrie a. Cancers (Basel). 2022 Dec 21;15(1):25. doi: 10.3390/cancers15010025. Cancers (Basel). 2022. PMID: 36612022 Free PMC article.