Prorok M - Search Results

1

A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide.

Dai Q, Castellino FJ, Prorok M. Dai Q, et al. Among authors: prorok m. Biochemistry. 2004 Oct 19;43(41):13225-32. doi: 10.1021/bi048796s. Biochemistry. 2004. PMID: 15476416

We have previously established that one of the conantokins, conantokin-G (con-G), self-associates in the presence of Ca(2+) with high specificity for antiparallel chain orientation [Dai, Q., Prorok, M., and Castellino, F. J. (2004) J. Mol. Biol. 336, 731-744]. ...

We have previously established that one of the conantokins, conantokin-G (con-G), self-associates in the presence of Ca(2+) with high specif …

2

Binding and orientation of conantokins in PL vesicles and aligned PL multilayers.

Dai Q, Zajicek J, Castellino FJ, Prorok M. Dai Q, et al. Among authors: prorok m. Biochemistry. 2003 Nov 4;42(43):12511-21. doi: 10.1021/bi034918p. Biochemistry. 2003. PMID: 14580197

With respect to the N-methyl-D-aspartate receptor (NMDAR), we have previously established a low affinity, nonreceptor-mediated interaction of the peptidic conantokins with synaptic membranes in conjunction with a high affinity binding to the NMDARs present therein [Klein, R. C., …

With respect to the N-methyl-D-aspartate receptor (NMDAR), we have previously established a low affinity, nonreceptor-mediated interaction o …

3

A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues.

Dai Q, Prorok M, Castellino FJ. Dai Q, et al. Among authors: prorok m. J Mol Biol. 2004 Feb 20;336(3):731-44. doi: 10.1016/j.jmb.2003.12.027. J Mol Biol. 2004. PMID: 15095984

4

Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties.

Dai Q, Prorok M, Castellino FJ. Dai Q, et al. Among authors: prorok m. Biochemistry. 2005 Sep 20;44(37):12508-14. doi: 10.1021/bi050974+. Biochemistry. 2005. PMID: 16156662

5

X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM.

Cnudde SE, Prorok M, Castellino FJ, Geiger JH. Cnudde SE, et al. Among authors: prorok m. Biochemistry. 2006 Sep 19;45(37):11052-60. doi: 10.1021/bi060914j. Biochemistry. 2006. PMID: 16964966

6

Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives.

Dai Q, Sheng Z, Geiger JH, Castellino FJ, Prorok M. Dai Q, et al. Among authors: prorok m. J Biol Chem. 2007 Apr 27;282(17):12641-9. doi: 10.1074/jbc.M609087200. Epub 2007 Mar 8. J Biol Chem. 2007. PMID: 17347154 Free article.

7

The molecular basis of conantokin antagonism of NMDA receptor function.

Prorok M, Castellino FJ. Prorok M, et al. Curr Drug Targets. 2007 May;8(5):633-42. doi: 10.2174/138945007780618481. Curr Drug Targets. 2007. PMID: 17504106 Review.

8

Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides.

Sheng Z, Dai Q, Prorok M, Castellino FJ. Sheng Z, et al. Among authors: prorok m. Neuropharmacology. 2007 Jul;53(1):145-56. doi: 10.1016/j.neuropharm.2007.04.016. Epub 2007 May 10. Neuropharmacology. 2007. PMID: 17588620 Free PMC article.

9

The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.

Sheng Z, Liang Z, Geiger JH, Prorok M, Castellino FJ. Sheng Z, et al. Among authors: prorok m. Neuropharmacology. 2009 Aug;57(2):127-36. doi: 10.1016/j.neuropharm.2009.04.014. Epub 2009 May 8. Neuropharmacology. 2009. PMID: 19427876 Free PMC article.

10

Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues.

Dai Q, Dong M, Liu Z, Prorok M, Castellino FJ. Dai Q, et al. Among authors: prorok m. J Inorg Biochem. 2011 Jan;105(1):52-7. doi: 10.1016/j.jinorgbio.2010.10.002. Epub 2010 Oct 8. J Inorg Biochem. 2011. PMID: 21134602 Free PMC article.

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