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Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.
Bruins W, Zwart E, Attardi LD, Iwakuma T, Hoogervorst EM, Beems RB, Miranda B, van Oostrom CT, van den Berg J, van den Aardweg GJ, Lozano G, van Steeg H, Jacks T, de Vries A. Bruins W, et al. Among authors: van den aardweg gj, van den berg j, van steeg h, van oostrom ct. Mol Cell Biol. 2004 Oct;24(20):8884-94. doi: 10.1128/MCB.24.20.8884-8894.2004. Mol Cell Biol. 2004. PMID: 15456863 Free PMC article.
Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas.
Hoogervorst EM, Bruins W, Zwart E, van Oostrom CT, van den Aardweg GJ, Beems RB, van den Berg J, Jacks T, van Steeg H, de Vries A. Hoogervorst EM, et al. Among authors: van den aardweg gj, van den berg j, van steeg h, van oostrom ct. Cancer Res. 2005 May 1;65(9):3610-6. doi: 10.1158/0008-5472.CAN-04-4328. Cancer Res. 2005. PMID: 15867355
2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair.
Hoogervorst EM, van Oostrom CT, Beems RB, van Benthem J, van den Berg J, van Kreijl CF, Vos JG, de Vries A, van Steeg H. Hoogervorst EM, et al. Among authors: van den berg j, van kreijl cf, van steeg h, van benthem j, van oostrom ct. DNA Repair (Amst). 2005 Jan 2;4(1):3-9. doi: 10.1016/j.dnarep.2004.08.009. DNA Repair (Amst). 2005. PMID: 15533832
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction.
Wijnhoven SW, Beems RB, Roodbergen M, van den Berg J, Lohman PH, Diderich K, van der Horst GT, Vijg J, Hoeijmakers JH, van Steeg H. Wijnhoven SW, et al. Among authors: van der horst gt, van den berg j, van steeg h. DNA Repair (Amst). 2005 Nov 21;4(11):1314-24. doi: 10.1016/j.dnarep.2005.07.002. Epub 2005 Aug 22. DNA Repair (Amst). 2005. PMID: 16115803
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.
Melis JP, Wijnhoven SW, Beems RB, Roodbergen M, van den Berg J, Moon H, Friedberg E, van der Horst GT, Hoeijmakers JH, Vijg J, van Steeg H. Melis JP, et al. Among authors: van der horst gt, van den berg j, van steeg h. Cancer Res. 2008 Mar 1;68(5):1347-53. doi: 10.1158/0008-5472.CAN-07-6067. Cancer Res. 2008. PMID: 18316597 Free article.
Evaluation of the Xpa-deficient transgenic mouse model for short-term carcinogenicity testing: 9-month studies with haloperidol, reserpine, phenacetin, and D-mannitol.
Lina BA, Woutersen RA, Bruijntjes JP, van Benthem J, van den Berg JA, Monbaliu J, Thoolen BJ, Beems RB, van Kreijl CF. Lina BA, et al. Among authors: van den berg ja, van kreijl cf, van benthem j. Toxicol Pathol. 2004 Mar-Apr;32(2):192-201. doi: 10.1080/01926230490274344. Toxicol Pathol. 2004. PMID: 15200157
1,295 results