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Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin.
Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP Jr. Thomas RR, et al. Among authors: khan sm. Mitochondrion. 2011 Jan;11(1):108-18. doi: 10.1016/j.mito.2010.08.004. Epub 2010 Aug 18. Mitochondrion. 2011. PMID: 20727424 Free PMC article.
RNA-seq analyses reveal that cervical spinal cords and anterior motor neurons from amyotrophic lateral sclerosis subjects show reduced expression of mitochondrial DNA-encoded respiratory genes, and rhTFAM may correct this respiratory deficiency.
Ladd AC, Brohawn DG, Thomas RR, Keeney PM, Berr SS, Khan SM, Portell FR, Shakenov MZ, Antkowiak PF, Kundu B, Tustison N, Bennett JP. Ladd AC, et al. Among authors: khan sm. Brain Res. 2017 Jul 15;1667:74-83. doi: 10.1016/j.brainres.2017.05.010. Epub 2017 May 13. Brain Res. 2017. PMID: 28511992
522 results