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In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803).
Camarda V, Spagnol M, Song W, Vergura R, Roth AL, Thompson JP, Rowbotham DJ, Guerrini R, Marzola E, Salvadori S, Cavanni P, Regoli D, Douglas SA, Lambert DG, Calò G. Camarda V, et al. Among authors: douglas sa. Br J Pharmacol. 2006 Jan;147(1):92-100. doi: 10.1038/sj.bjp.0706438. Br J Pharmacol. 2006. PMID: 16273120 Free PMC article.
The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems.
Behm DJ, Stankus G, Doe CP, Willette RN, Sarau HM, Foley JJ, Schmidt DB, Nuthulaganti P, Fornwald JA, Ames RS, Lambert DG, Calo' G, Camarda V, Aiyar NV, Douglas SA. Behm DJ, et al. Among authors: douglas sa. Br J Pharmacol. 2006 May;148(2):173-90. doi: 10.1038/sj.bjp.0706716. Br J Pharmacol. 2006. PMID: 16547525 Free PMC article.
Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues.
Behm DJ, McAtee JJ, Dodson JW, Neeb MJ, Fries HE, Evans CA, Hernandez RR, Hoffman KD, Harrison SM, Lai JM, Wu C, Aiyar NV, Ohlstein EH, Douglas SA. Behm DJ, et al. Among authors: douglas sa. Br J Pharmacol. 2008 Oct;155(3):374-86. doi: 10.1038/bjp.2008.266. Epub 2008 Jun 30. Br J Pharmacol. 2008. PMID: 18587423 Free PMC article.
Urotensin-II: a novel systemic hypertensive factor in the cat.
Behm DJ, Doe CP, Johns DG, Maniscalco K, Stankus GP, Wibberley A, Willette RN, Douglas SA. Behm DJ, et al. Among authors: douglas sa. Naunyn Schmiedebergs Arch Pharmacol. 2004 Mar;369(3):274-80. doi: 10.1007/s00210-004-0873-1. Epub 2004 Feb 19. Naunyn Schmiedebergs Arch Pharmacol. 2004. PMID: 14985938
138 results