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The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.
Strecker TE, Odutola SO, Lopez R, Cooper MS, Tidmore JK, Charlton-Sevcik AK, Li L, MacDonough MT, Hadimani MB, Ghatak A, Liu L, Chaplin DJ, Mason RP, Pinney KG, Trawick ML. Strecker TE, et al. Among authors: chaplin dj. Cancer Lett. 2015 Dec 1;369(1):229-41. doi: 10.1016/j.canlet.2015.08.021. Epub 2015 Sep 1. Cancer Lett. 2015. PMID: 26325604 Free PMC article.
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.
Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. Hadimani MB, et al. Among authors: chaplin dj. J Nat Prod. 2013 Sep 27;76(9):1668-78. doi: 10.1021/np400374w. Epub 2013 Sep 9. J Nat Prod. 2013. PMID: 24016002 Free PMC article.
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
Devkota L, Lin CM, Strecker TE, Wang Y, Tidmore JK, Chen Z, Guddneppanavar R, Jelinek CJ, Lopez R, Liu L, Hamel E, Mason RP, Chaplin DJ, Trawick ML, Pinney KG. Devkota L, et al. Among authors: chaplin dj. Bioorg Med Chem. 2016 Mar 1;24(5):938-956. doi: 10.1016/j.bmc.2016.01.007. Epub 2016 Jan 6. Bioorg Med Chem. 2016. PMID: 26852340 Free PMC article.
210 results