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Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet.
Am J Pathol. 2004 Jul;165(1):283-97. doi: 10.1016/s0002-9440(10)63296-8.
Am J Pathol. 2004.
PMID: 15215183
Free PMC article.
The generation and characterization of potentially therapeutic Abeta antibodies in mice: differences according to strain and immunization protocol.
Spooner ET, Desai RV, Mori C, Leverone JF, Lemere CA.
Spooner ET, et al. Among authors: leverone jf.
Vaccine. 2002 Dec 13;21(3-4):290-7. doi: 10.1016/s0264-410x(02)00464-4.
Vaccine. 2002.
PMID: 12450704
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Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants.
Lemere CA, Spooner ET, Leverone JF, Mori C, Clements JD.
Lemere CA, et al. Among authors: leverone jf.
Neurobiol Aging. 2002 Nov-Dec;23(6):991-1000. doi: 10.1016/s0197-4580(02)00127-6.
Neurobiol Aging. 2002.
PMID: 12470794
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Abeta1-15 is less immunogenic than Abeta1-40/42 for intranasal immunization of wild-type mice but may be effective for "boosting".
Leverone JF, Spooner ET, Lehman HK, Clements JD, Lemere CA.
Leverone JF, et al.
Vaccine. 2003 May 16;21(17-18):2197-206. doi: 10.1016/s0264-410x(02)00754-5.
Vaccine. 2003.
PMID: 12706711
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Amyloid-beta immunization in Alzheimer's disease transgenic mouse models and wildtype mice.
Lemere CA, Spooner ET, Leverone JF, Mori C, Iglesias M, Bloom JK, Seabrook TJ.
Lemere CA, et al. Among authors: leverone jf.
Neurochem Res. 2003 Jul;28(7):1017-27. doi: 10.1023/a:1023203122036.
Neurochem Res. 2003.
PMID: 12737526
Review.
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Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.
Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE.
Lemere CA, et al. Among authors: leverone jf.
Neurobiol Dis. 2003 Oct;14(1):10-8. doi: 10.1016/s0969-9961(03)00044-5.
Neurobiol Dis. 2003.
PMID: 13678662
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Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta).
Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, St George Hyslop P, Holtzman DM, Walker LC, Keller ET.
Gandy S, et al.
Mech Ageing Dev. 2004 Feb;125(2):149-51. doi: 10.1016/j.mad.2003.12.002.
Mech Ageing Dev. 2004.
PMID: 15037022
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Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).
Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, Hyslop PS, Holtzman DM, Walker LC, Keller ET.
Gandy S, et al.
Alzheimer Dis Assoc Disord. 2004 Jan-Mar;18(1):44-6. doi: 10.1097/00002093-200401000-00009.
Alzheimer Dis Assoc Disord. 2004.
PMID: 15195463
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