Ernst JT - Search Results

1

Protein recognition using synthetic surface-targeted agents.

Jain R, Ernst JT, Kutzki O, Park HS, Hamilton AD. Jain R, et al. Among authors: ernst jt. Mol Divers. 2004;8(2):89-100. doi: 10.1023/b:modi.0000025652.55320.16. Mol Divers. 2004. PMID: 15209160 Review.

2

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry.

Kutzki O, Park HS, Ernst JT, Orner BP, Yin H, Hamilton AD. Kutzki O, et al. Among authors: ernst jt. J Am Chem Soc. 2002 Oct 9;124(40):11838-9. doi: 10.1021/ja026861k. J Am Chem Soc. 2002. PMID: 12358513

3

Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion.

Ernst JT, Kutzki O, Debnath AK, Jiang S, Lu H, Hamilton AD. Ernst JT, et al. Angew Chem Int Ed Engl. 2002 Jan 18;41(2):278-81. doi: 10.1002/1521-3773(20020118)41:2<278::aid-anie278>3.0.co;2-a. Angew Chem Int Ed Engl. 2002. PMID: 12491408 No abstract available.

4

Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex.

Ernst JT, Becerril J, Park HS, Yin H, Hamilton AD. Ernst JT, et al. Angew Chem Int Ed Engl. 2003 Feb 3;42(5):535-9. doi: 10.1002/anie.200390154. Angew Chem Int Ed Engl. 2003. PMID: 12569483 No abstract available.

5

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

Yin H, Lee GI, Sedey KA, Kutzki O, Park HS, Orner BP, Ernst JT, Wang HG, Sebti SM, Hamilton AD. Yin H, et al. Among authors: ernst jt. J Am Chem Soc. 2005 Jul 27;127(29):10191-6. doi: 10.1021/ja050122x. J Am Chem Soc. 2005. PMID: 16028929

6

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix.

Orner BP, Ernst JT, Hamilton AD. Orner BP, et al. Among authors: ernst jt. J Am Chem Soc. 2001 Jun 6;123(22):5382-3. doi: 10.1021/ja0025548. J Am Chem Soc. 2001. PMID: 11457415 No abstract available.

7

XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41.

Zhao Q, Ernst JT, Hamilton AD, Debnath AK, Jiang S. Zhao Q, et al. Among authors: ernst jt. AIDS Res Hum Retroviruses. 2002 Sep 20;18(14):989-97. doi: 10.1089/08892220260235353. AIDS Res Hum Retroviruses. 2002. PMID: 12396451

8

1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties.

Nilewski C, Michels TD, Packard GK, Xiang AX, Sprengeler PA, Eam B, Fish S, Thompson PA, Wegerski CJ, Nevarez A, Clarine J, Sperry S, Ernst JT, Reich SH. Nilewski C, et al. Among authors: ernst jt. Bioorg Med Chem Lett. 2021 Sep 1;47:128111. doi: 10.1016/j.bmcl.2021.128111. Epub 2021 Aug 2. Bioorg Med Chem Lett. 2021. PMID: 34353608

9

Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.

Thompson PA, Eam B, Young NP, Fish S, Chen J, Barrera M, Howard H, Sung E, Parra A, Staunton J, Chiang GG, Gerson-Gurwitz A, Wegerski CJ, Nevarez A, Clarine J, Sperry S, Xiang A, Nilewski C, Packard GK, Michels T, Tran C, Sprengeler PA, Ernst JT, Reich SH, Webster KR. Thompson PA, et al. Among authors: ernst jt. Mol Cancer Ther. 2021 Jan;20(1):26-36. doi: 10.1158/1535-7163.MCT-19-0973. Epub 2020 Oct 9. Mol Cancer Ther. 2021. PMID: 33037136

10

Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors.

Nilewski C, Michels TD, Xiang AX, Packard GK, Sprengeler PA, Eam B, Fish S, Thompson PA, Wegerski CJ, Ernst JT, Reich SH. Nilewski C, et al. Among authors: ernst jt. Org Lett. 2020 Aug 21;22(16):6257-6261. doi: 10.1021/acs.orglett.0c01944. Epub 2020 Jul 30. Org Lett. 2020. PMID: 32806219

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