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Polyarginines are potent furin inhibitors.
Cameron A, Appel J, Houghten RA, Lindberg I. Cameron A, et al. Among authors: houghten ra. J Biol Chem. 2000 Nov 24;275(47):36741-9. doi: 10.1074/jbc.M003848200. J Biol Chem. 2000. PMID: 10958789 Free article.
Synthetic small-molecule prohormone convertase 2 inhibitors.
Kowalska D, Liu J, Appel JR, Ozawa A, Nefzi A, Mackin RB, Houghten RA, Lindberg I. Kowalska D, et al. Among authors: houghten ra. Mol Pharmacol. 2009 Mar;75(3):617-25. doi: 10.1124/mol.108.051334. Epub 2008 Dec 12. Mol Pharmacol. 2009. PMID: 19074544 Free PMC article.
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
Levesque C, Fugère M, Kwiatkowska A, Couture F, Desjardins R, Routhier S, Moussette P, Prahl A, Lammek B, Appel JR, Houghten RA, D'Anjou F, Dory YL, Neugebauer W, Day R. Levesque C, et al. Among authors: houghten ra. J Med Chem. 2012 Dec 13;55(23):10501-11. doi: 10.1021/jm3011178. Epub 2012 Nov 14. J Med Chem. 2012. PMID: 23126600 Free PMC article.
407 results