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The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase.
Wilson JE, Martin JL, Borroto-Esoda K, Hopkins S, Painter G, Liotta DC, Furman PA. Wilson JE, et al. Among authors: liotta dc. Antimicrob Agents Chemother. 1993 Aug;37(8):1720-2. doi: 10.1128/AAC.37.8.1720. Antimicrob Agents Chemother. 1993. PMID: 7692813 Free PMC article.
Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus.
Frick LW, St John L, Taylor LC, Painter GR, Furman PA, Liotta DC, Furfine ES, Nelson DJ. Frick LW, et al. Among authors: liotta dc. Antimicrob Agents Chemother. 1993 Nov;37(11):2285-92. doi: 10.1128/AAC.37.11.2285. Antimicrob Agents Chemother. 1993. PMID: 8285607 Free PMC article.
Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent.
Mao S, Bouygues M, Welch C, Biba M, Chilenski J, Schinazi RF, Liotta DC. Mao S, et al. Among authors: liotta dc. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4991-4. doi: 10.1016/j.bmcl.2004.07.016. Bioorg Med Chem Lett. 2004. PMID: 15341966
Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys.
Hernandez-Santiago BI, Chen H, Asif G, Beltran T, Mao S, Hurwitz SJ, Grier J, McClure HM, Chu CK, Liotta DC, Schinazi RF. Hernandez-Santiago BI, et al. Among authors: liotta dc. Antimicrob Agents Chemother. 2005 Jul;49(7):2589-97. doi: 10.1128/AAC.49.7.2589-2597.2005. Antimicrob Agents Chemother. 2005. PMID: 15980324 Free PMC article.
An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.
Krumm SA, Yan D, Hovingh ES, Evers TJ, Enkirch T, Reddy GP, Sun A, Saindane MT, Arrendale RF, Painter G, Liotta DC, Natchus MG, von Messling V, Plemper RK. Krumm SA, et al. Among authors: liotta dc. Sci Transl Med. 2014 Apr 16;6(232):232ra52. doi: 10.1126/scitranslmed.3008517. Sci Transl Med. 2014. PMID: 24739760 Free PMC article.
289 results