Ashcroft M - Search Results

1

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.

Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W Jr, Koch CJ, Maxwell P, Mitchell J, Neckers L, Powis G, Rajendran J, Semenza GL, Simons J, Storkebaum E, Welch MJ, Whitelaw M, Melillo G, Ivy SP. Kaufman B, et al. Among authors: ashcroft m. Cancer Res. 2004 May 1;64(9):3350-6. doi: 10.1158/0008-5472.can-03-2611. Cancer Res. 2004. PMID: 15126380 No abstract available.

2

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

Poon E, Harris AL, Ashcroft M. Poon E, et al. Among authors: ashcroft m. Expert Rev Mol Med. 2009 Aug 27;11:e26. doi: 10.1017/S1462399409001173. Expert Rev Mol Med. 2009. PMID: 19709449 Review.

3

Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection.

Harten SK, Ashcroft M, Maxwell PH. Harten SK, et al. Among authors: ashcroft m. Antioxid Redox Signal. 2010 Apr;12(4):459-80. doi: 10.1089/ars.2009.2870. Antioxid Redox Signal. 2010. PMID: 19737089 Review.

4

Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.

Harten SK, Esteban MA, Shukla D, Ashcroft M, Maxwell PH. Harten SK, et al. Among authors: ashcroft m. Mol Cancer. 2011 Jul 26;10:89. doi: 10.1186/1476-4598-10-89. Mol Cancer. 2011. PMID: 21791076 Free PMC article.

5

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.

Yang J, Staples O, Thomas LW, Briston T, Robson M, Poon E, Simões ML, El-Emir E, Buffa FM, Ahmed A, Annear NP, Shukla D, Pedley BR, Maxwell PH, Harris AL, Ashcroft M. Yang J, et al. Among authors: ashcroft m. J Clin Invest. 2012 Feb;122(2):600-11. doi: 10.1172/JCI58780. Epub 2012 Jan 3. J Clin Invest. 2012. PMID: 22214851 Free PMC article.

6

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

Luong le A, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JL, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC. Luong le A, et al. Among authors: ashcroft m. Circ Res. 2013 Jun 7;112(12):1583-91. doi: 10.1161/CIRCRESAHA.111.300119. Epub 2013 Apr 5. Circ Res. 2013. PMID: 23564640 Free PMC article.

7

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.

Khan MN, Bhattacharyya T, Andrikopoulos P, Esteban MA, Barod R, Connor T, Ashcroft M, Maxwell PH, Kiriakidis S. Khan MN, et al. Among authors: ashcroft m. Br J Cancer. 2011 Mar 29;104(7):1151-9. doi: 10.1038/bjc.2011.73. Epub 2011 Mar 8. Br J Cancer. 2011. PMID: 21386837 Free PMC article.

8

Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway.

Carroll VA, Ashcroft M. Carroll VA, et al. Among authors: ashcroft m. Cancer Res. 2006 Jun 15;66(12):6264-70. doi: 10.1158/0008-5472.CAN-05-2519. Cancer Res. 2006. PMID: 16778202

9

Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors.

Chau NM, Rogers P, Aherne W, Carroll V, Collins I, McDonald E, Workman P, Ashcroft M. Chau NM, et al. Among authors: ashcroft m. Cancer Res. 2005 Jun 1;65(11):4918-28. doi: 10.1158/0008-5472.CAN-04-4453. Cancer Res. 2005. PMID: 15930314

10

Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20).

Burrows N, Cane G, Robson M, Gaude E, Howat WJ, Szlosarek PW, Pedley RB, Frezza C, Ashcroft M, Maxwell PH. Burrows N, et al. Among authors: ashcroft m. Sci Rep. 2016 Mar 14;6:22950. doi: 10.1038/srep22950. Sci Rep. 2016. PMID: 26972697 Free PMC article.

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