Freidinger RM - Search Results

1

Progress towards the development of a HIV-1 gp41-directed vaccine.

McGaughey GB, Barbato G, Bianchi E, Freidinger RM, Garsky VM, Hurni WM, Joyce JG, Liang X, Miller MD, Pessi A, Shiver JW, Bogusky MJ. McGaughey GB, et al. Among authors: freidinger rm. Curr HIV Res. 2004 Apr;2(2):193-204. doi: 10.2174/1570162043484933. Curr HIV Res. 2004. PMID: 15078183 Review.

2

HIV-1 vaccine development: constrained peptide immunogens show improved binding to the anti-HIV-1 gp41 MAb.

McGaughey GB, Citron M, Danzeisen RC, Freidinger RM, Garsky VM, Hurni WM, Joyce JG, Liang X, Miller M, Shiver J, Bogusky MJ. McGaughey GB, et al. Among authors: freidinger rm. Biochemistry. 2003 Mar 25;42(11):3214-23. doi: 10.1021/bi026952u. Biochemistry. 2003. PMID: 12641452

3

Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs.

Garsky VM, Lumma PK, Freidinger RM, Pitzenberger SM, Randall WC, Veber DF, Gould RJ, Friedman PA. Garsky VM, et al. Among authors: freidinger rm. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4022-6. doi: 10.1073/pnas.86.11.4022. Proc Natl Acad Sci U S A. 1989. PMID: 2726764 Free PMC article.

4

Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity.

Brady SF, Pawluczyk JM, Lumma PK, Feng DM, Wai JM, Jones R, DeFeo-Jones D, Wong BK, Miller-Stein C, Lin JH, Oliff A, Freidinger RM, Garsky VM. Brady SF, et al. Among authors: freidinger rm. J Med Chem. 2002 Oct 10;45(21):4706-15. doi: 10.1021/jm020139f. J Med Chem. 2002. PMID: 12361397

5

HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins.

Darke PL, Nutt RF, Brady SF, Garsky VM, Ciccarone TM, Leu CT, Lumma PK, Freidinger RM, Veber DF, Sigal IS. Darke PL, et al. Among authors: freidinger rm. Biochem Biophys Res Commun. 1988 Oct 14;156(1):297-303. doi: 10.1016/s0006-291x(88)80839-8. Biochem Biophys Res Commun. 1988. PMID: 3052448

6

The synthesis of a prodrug of doxorubicin designed to provide reduced systemic toxicity and greater target efficacy.

Garsky VM, Lumma PK, Feng DM, Wai J, Ramjit HG, Sardana MK, Oliff A, Jones RE, DeFeo-Jones D, Freidinger RM. Garsky VM, et al. Among authors: freidinger rm. J Med Chem. 2001 Nov 22;44(24):4216-24. doi: 10.1021/jm0101996. J Med Chem. 2001. PMID: 11708923

7

Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications.

Freidinger RM, Williams PD, Tung RD, Bock MG, Pettibone DJ, Clineschmidt BV, DiPardo RM, Erb JM, Garsky VM, Gould NP, et al. Freidinger RM, et al. J Med Chem. 1990 Jul;33(7):1843-5. doi: 10.1021/jm00169a001. J Med Chem. 1990. PMID: 2163451 No abstract available.

8

A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo.

DeFeo-Jones D, Garsky VM, Wong BK, Feng DM, Bolyar T, Haskell K, Kiefer DM, Leander K, McAvoy E, Lumma P, Wai J, Senderak ET, Motzel SL, Keenan K, Van Zwieten M, Lin JH, Freidinger R, Huff J, Oliff A, Jones RE. DeFeo-Jones D, et al. Nat Med. 2000 Nov;6(11):1248-52. doi: 10.1038/81351. Nat Med. 2000. PMID: 11062536

9

Progress in the development of oxytocin antagonists for use in preterm labor.

Williams PD, Bock MG, Evans BE, Freidinger RM, Pettibone DJ. Williams PD, et al. Among authors: freidinger rm. Adv Exp Med Biol. 1998;449:473-9. doi: 10.1007/978-1-4615-4871-3_61. Adv Exp Med Biol. 1998. PMID: 10026841

10

A prostate-specific antigen (PSA)-activated vinblastine prodrug selectively kills PSA-secreting cells in vivo.

DeFeo-Jones D, Brady SF, Feng DM, Wong BK, Bolyar T, Haskell K, Kiefer DM, Leander K, McAvoy E, Lumma P, Pawluczyk JM, Wai J, Motzel SL, Keenan K, Van Zwieten M, Lin JH, Garsky VM, Freidinger R, Oliff A, Jones RE. DeFeo-Jones D, et al. Mol Cancer Ther. 2002 May;1(7):451-9. Mol Cancer Ther. 2002. PMID: 12479263

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