O'Dwyer K - Search Results

1

Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth.

O'Dwyer K, Watts JM, Biswas S, Ambrad J, Barber M, Brulé H, Petit C, Holmes DJ, Zalacain M, Holmes WM. O'Dwyer K, et al. J Bacteriol. 2004 Apr;186(8):2346-54. doi: 10.1128/JB.186.8.2346-2354.2004. J Bacteriol. 2004. PMID: 15060037 Free PMC article.

2

Characterization of a novel fucose-regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae.

Chan PF, O'Dwyer KM, Palmer LM, Ambrad JD, Ingraham KA, So C, Lonetto MA, Biswas S, Rosenberg M, Holmes DJ, Zalacain M. Chan PF, et al. J Bacteriol. 2003 Mar;185(6):2051-8. doi: 10.1128/JB.185.6.2051-2058.2003. J Bacteriol. 2003. PMID: 12618474 Free PMC article.

3

A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function.

Zalacain M, Biswas S, Ingraham KA, Ambrad J, Bryant A, Chalker AF, Iordanescu S, Fan J, Fan F, Lunsford RD, O'Dwyer K, Palmer LM, So C, Sylvester D, Volker C, Warren P, McDevitt D, Brown JR, Holmes DJ, Burnham MK. Zalacain M, et al. J Mol Microbiol Biotechnol. 2003;6(2):109-26. doi: 10.1159/000076741. J Mol Microbiol Biotechnol. 2003. PMID: 15044829

4

Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.

Min S, Ingraham K, Huang J, McCloskey L, Rilling S, Windau A, Pizzollo J, Butler D, Aubart K, Miller LA, Zalacain M, Holmes DJ, O'Dwyer K. Min S, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4644-52. doi: 10.1128/AAC.00484-15. Epub 2015 May 26. Antimicrob Agents Chemother. 2015. PMID: 26014938 Free PMC article.

5

Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.

O'Dwyer K, Hackel M, Hightower S, Hoban D, Bouchillon S, Qin D, Aubart K, Zalacain M, Butler D. O'Dwyer K, et al. Antimicrob Agents Chemother. 2013 May;57(5):2333-42. doi: 10.1128/AAC.02566-12. Epub 2013 Mar 11. Antimicrob Agents Chemother. 2013. PMID: 23478958 Free PMC article.

6

Potent sub-MIC effect of GSK1322322 and other peptide deformylase inhibitors on in vitro growth of Staphylococcus aureus.

Butler D, Chen D, O'Dwyer K, Lewandowski T, Aubart K, Zalacain M. Butler D, et al. Antimicrob Agents Chemother. 2014;58(1):290-6. doi: 10.1128/AAC.01292-13. Epub 2013 Oct 28. Antimicrob Agents Chemother. 2014. PMID: 24165188 Free PMC article.

7

Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.

O'Dwyer K, Spivak AT, Ingraham K, Min S, Holmes DJ, Jakielaszek C, Rittenhouse S, Kwan AL, Livi GP, Sathe G, Thomas E, Van Horn S, Miller LA, Twynholm M, Tomayko J, Dalessandro M, Caltabiano M, Scangarella-Oman NE, Brown JR. O'Dwyer K, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. doi: 10.1128/AAC.03774-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348524 Free PMC article. Clinical Trial.

8

Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague.

Jakielaszek C, Hossain M, Qian L, Fishman C, Widdowson K, Hilliard JJ, Mannino F, Raychaudhuri A, Carniel E, Demons S, Heine HS, Hershfield J, Russo R, Mega WM, Revelli D, O'Dwyer K. Jakielaszek C, et al. Sci Transl Med. 2022 Jun;14(647):eabg1787. doi: 10.1126/scitranslmed.abg1787. Epub 2022 Jun 1. Sci Transl Med. 2022. PMID: 35648812

9

Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors.

Bruton G, Huxley A, O'Hanlon P, Orlek B, Eggleston D, Humphries J, Readshaw S, West A, Ashman S, Brown M, Moore K, Pope A, O'Dwyer K, Wang L. Bruton G, et al. Eur J Med Chem. 2003 Apr;38(4):351-6. doi: 10.1016/s0223-5234(03)00040-0. Eur J Med Chem. 2003. PMID: 12750021

10

Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production.

Bailey AM, Alberti F, Kilaru S, Collins CM, de Mattos-Shipley K, Hartley AJ, Hayes P, Griffin A, Lazarus CM, Cox RJ, Willis CL, O'Dwyer K, Spence DW, Foster GD. Bailey AM, et al. Sci Rep. 2016 May 4;6:25202. doi: 10.1038/srep25202. Sci Rep. 2016. PMID: 27143514 Free PMC article.

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